136188-94-8

Upstream product

• 329004-08-2 tert-butyl 4-(4-aminophenethyl)piperazine-1-carboxylate 
• 130636-60-1 4-[2-(4-nitro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 329004-09-3 4-[2-(4-methanesulfonylamino-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and class III type antiarrhythmic activity of 4-Aroyl (and Aryl)-1-aralkylpiperazines

The synthesis and in vitro Class III antiarrhythmic activity of several 4-aroyl (and aryl)-1-aralkylpiperazine and piperidine derivatives are described. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC20 of 3 nM, ranks as one of the most potent (in vitro) compounds reported. (C) 2000 Elsevier Science Ltd.

Benzofuran compounds as class III antiarrhythmic agents

Compounds of structural formula: STR1 wherein R' is hydrogen or an aromatic ring system, and Q is a substituted nitrogen or a nitrogen containing heterocycle, X and Y are bridging groups and p is 0 or 1, and E is --S-- or --O--, are Class III antiarrhythmic agents.

Class III antiarrhythmic agents

Compounds of structural formula: STR1 wherein R' is hydrogen or an aromatic ring system, and Q is a substituted nitrogen or a nitrogen containing heterocycle, and E is --S-- or --O--, are Class III antiarrhythmic agents.