130696-25-2Relevant academic research and scientific papers
Efficient asymmetric hydrogenation of α-acetamidocinnamates through a simple, readily available monodentate chiral H-phosphinate
Wang, Xiang-Bo,Goto, Midori,Han, Li-Biao
supporting information, p. 3631 - 3635 (2014/04/03)
An air-stable, simple (RP)-mentylbenzylphosphinate, readily available in large quantities, can efficiently induce the rhodium-catalyzed asymmetric hydrogenation of α-acetamidocinnamates with high enantioselectivity (up to 99.6 % ee). Intramolecular hydrogen bonding plays an important role in this asymmetric induction.
The asymmetric synthesis of α-substituted α-methyl and α-phenyl phosphonic acids: Design, carbanion geometry, reactivity and preparative aspects of chiral alkyl bicyclic phosphonamides
Bennani, Youssef L.,Hanessian, Stephen
, p. 13837 - 13866 (2007/10/03)
The design, preparation, structural and spectroscopic analyses of topologically unique and enantiomerically pure alkyl phosphonamides are described. In the case of α-ethyl and α-benzyl phosphonamides, the geometry of both the secondary and tertiary carbanions was determined to be planar through deprotonation/deuteration/alkylation experiments. Stereoselective alkylations of such systems proceeded in good yields and with high diastereoselectivities. The resulting α,α-alkylated phosphonamides were hydrolyzed to give the corresponding α,α-alkyl phosphonic acids with high degrees of enantiomeric purity.
Alkylations of chiral, phosphoryl- and thiophosphoryl-stabilized carbanions
Denmark, Scott E.,Chen, Chien-Tien
, p. 11879 - 11897 (2007/10/03)
A general method for the preparation of enantiomerically enriched phosphonic acids and phosphonates with three different α-substitution patterns (aryl, alkyl, and alkoxy) has been developed. Anions derived from enantiomerically enriched thiophosphonamidat
Stereoselective Alkylations of Chiral, Phosphorus-Stabilized Benzylic Carbanions
Denmark, Scott E.,Dorow, Roberta L.
, p. 5926 - 5928 (2007/10/02)
A series of 6-substituted 2-benzyl-3-tert-butyl-1,3,2-oxazaphosphorinanes was prepared in racemic and enantiomerically pure form.The diastereoselectivity of alkylation of the derived anions was examined as a function of ring substitution pattern, base, so
