1499-19-0Relevant articles and documents
HIV-1 non-nucleoside reverse transcriptase inhibitors: Incorporation of benzylphosphonate moiety for solubility improvement
Matyugina, Elena S.,Valuev-Elliston, Vladimir T.,Chizhov, Alexander O.,Kochetkov, Sergei N.,Khandazhinskaya, Anastasia L.
, p. 114 - 116 (2016)
Benzylphosphonates of 5'-norcarbocyclic analogue of 2',3'-dideoxy-2',3'-didehydrouridine and its N3-benzyl derivatives with different substituents at the phosphorus atom were designed and synthesized in attempt to improve solubility of potentia
Diastereoselective synthesis of α,α′-disubstituted β-ketophosphonates derivatives as building blocks for automated syntheses
Pirat, Jean-Luc,Marat, Xavier,Clarion, Ludovic,Van Der Lee, Arie,Vors, Jean-Pierre,Cristau, Henri-Jean
, p. 2626 - 2637 (2007/10/03)
A convenient and efficient synthesis of α,α′- disubstituted β-ketophosphonic derivatives in good to excellent de's and yields has been achieved by α-acylation followed by diastereoselective α-alkylation of chiral 5-membered cyclic phosphonamidates.
Preparation of chiral α-monofluoroalkylphosphonic acids and their evaluation as inhibitors of protein tyrosine phosphatase 1B
Kotoris, Christopher C.,Wen, Wcndy,Lough, Alan,Taylor, Scott D.
, p. 1271 - 1281 (2007/10/03)
Enantiomerically pure α-monofluoroalkylphosphonic acids 4-9 were synthesized by diastereoselective electrophilic fluorination of α-carbanions of asymmetric phosphonamidates bearing (-)-ephedrine as a chiral auxiliary. The diastereomeric excess of the fluo
