1307232-38-7

Upstream product

• 100-52-7 benzaldehyde 
• 88-75-5 2-hydroxynitrobenzene 
• 74965-31-4 N-(tert-butoxycarbonyl)-o-toluidine 
• 931-53-3 Cyclohexyl isocyanide 
• 1307232-26-3 1-cyclohexyl-4-(2-nitrophenyl)-3-phenyl-3,4-dihydropyrazin-2(1H)-one 

Relevant academic research and scientific papers

Synthesis of 1,2-dihydrobenzo[4, 5]imidazo[1, 2-a]pyrazine-3(4H)-one derivatives

The invention relates to a preparation method of 1,2-dihydrobenzo[4, 5]imidazo[1, 2-a]pyrazine-3(4H)-one derivatives. The preparation method disclosed by the invention comprises the following steps: taking a Ugi reaction as a basis, performing deprotection under acid conditions, and performing microwave-assisted ring closure to obtain benzimidazole products; performing simple after-treatment, andpreparing the 1,2-dihydrobenzo[4, 5]imidazo[1, 2-a]pyrazine-3(4H)-one derivatives having potential antitumor activities under alkaline conditions. Compared with the traditional method, the method hasthe characteristics of being readily available in raw materials, simple and short in synthetic process, simple in after-treatment, high in yield and the like.

Multicomponent synthesis of fused benzimidazolopiperazines

We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclizat