13073-28-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-2-hydroxybenzonitrile is used as a key intermediate in the synthesis of pharmaceutical products due to its reactivity and ability to be incorporated into complex molecular structures. Its nucleophilic properties facilitate the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-2-hydroxybenzonitrile serves as a precursor in the development of agrochemicals, contributing to the production of pesticides and other compounds that protect crops and enhance agricultural productivity.
Used in Dye and Pigment Production:
3-Bromo-2-hydroxybenzonitrile is utilized as a precursor in the manufacturing process of dyes and pigments, where its chemical structure contributes to the color and stability of the final products, finding applications in various industries such as textiles, plastics, and inks.
Used in Organic Synthesis:
As a building block in organic synthesis, 3-Bromo-2-hydroxybenzonitrile is used for the creation of a wide range of organic compounds. Its strong nucleophilic nature allows it to participate in numerous chemical reactions, leading to the formation of diverse chemical entities for various applications across different industries.

Upstream product

• 611-20-1 salicylonitrile 
• 840481-82-5 3-bromo-2-fluoro-benzonitrile 
• 50-00-0 formaldehyd 
• 95-56-7 2-hydroxybromobenzene 
• 862992-93-6 2-benzyloxy-3-bromo-benzonitrile 
• 1829-34-1 2-hydroxy-3-bromobenzaldehyde 

Downstream Products

• 862992-94-7 C₁₀H₈BrNO₂ 
• 937254-51-8 2-[(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methoxy]-3-bromobenzonitrile 
• 874472-98-7 3-bromo-2-methoxybenzonitrile 
• 1268833-81-3 2-bromo-6-(5,6-dihydro-4H-1,3-oxazin-2-yl)phenol 
• 791136-88-4 3-bromo-2-methoxybenzamide 
• 1251588-69-8 C₃₀H₂₇N₅O₄ 

Relevant academic research and scientific papers

CRYSTALLINE FORMS OF SOMATOSTATIN MODULATORS

Described herein are pharmaceutically acceptable salts of a somatostatin modulator, crystalline forms of the pharmaceutically acceptable salts of the somatostatin modulator, methods of making such salts and crystalline forms, pharmaceutical compositions and medicaments comprising such salts and crystalline forms, and methods of using such salts and crystalline forms in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

PROCESS OF MAKING SOMATOSTATIN MODULATORS

Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

Chromatography-free entry to substituted salicylonitriles: Mitsunobu-triggered domino reactions of salicylaldoximes

A mild and efficient one-pot procedure is described to transform salicylaldoximes into salicylonitriles using Mitsunobu chemistry. The reactions proceed through the corresponding 1,2-benzisoxazoles that undergo the Kemp elimination in situ to generate the

Facile one-pot transformation of phenols into o-cyanophenols

The treatment of phenols with paraformaldehyde in the presence of MgCl2 and Et3N in THF at 80 C, followed by reaction with molecular iodine and aq. ammonia at room temperature provided the corresponding o-cyanophenols in moderate to good yields. The present reaction is a one-pot transformation of phenols into o-cyanophenols using much less expensive reagents than are typically used; the reaction is free of both transition-metals and cyanide. The utility of this reaction was highlighted during our preparation of Febuxostat from p-bromophenol.

NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS

Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.

METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS

A method of treatment using pharmaceutical compositions containing novel antagonists or inverse agonists at opioid receptors for the treatment of binge eating disorder, anorexia nervosa, bulimia nervosa, excess drug or alcohol use, or eating disorder not otherwise specified.

DI-SUBSTITUTED PHENYL COMPOUNDS

Di-substituted phenyl compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) f

A one-pot synthesis of substituted salicylnitriles

Phenols were converted to salicylaldehydes with paraformaldehyde, MgCl2-Et3N in THF, and subsequent treatment with aqueous ammonia gave the corresponding imines which were oxidized with IBX to the desired salicylnitriles. The sequence of reactions was conveniently carried out as a one-pot procedure under mild conditions.

CALCILYTIC COMPOUNDS

Novel calcilytic compounds and methods of using them are provided.