1307313-09-2Relevant articles and documents
Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7′-thieno[2,3- C ]pyran) scaffold
Toledo, Miguel A.,Pedregal, Concepción,Lafuente, Celia,Diaz, Nuria,Martinez-Grau, Maria Angeles,Jiménez, Alma,Benito, Ana,Torrado, Alicia,Mateos, Carlos,Joshi, Elizabeth M.,Kahl, Steven D.,Rash, Karen S.,Mudra, Daniel R.,Barth, Vanessa N.,Shaw, David B.,McKinzie, David,Witkin, Jeffrey M.,Statnick, Michael A.
, p. 3418 - 3429 (2014/05/20)
Nociceptin/OFQ (N/OFQ) is a 17 amino acid peptide that is the endogenous ligand for the ORL1/NOP receptor. Nociceptin appears to regulate a host of physiological functions such as biological reactions to stress, anxiety, mood, and drug abuse, in addition