130754-15-3

Basic information

• Product Name: ethyl 2-fluoro-2-(3-methoxyphenyl)acetate
• Synonyms: ethyl 2-fluoro-2-(3-methoxyphenyl)acetate
• CAS NO: 130754-15-3
• Molecular Weight: 212.221
• Mol File: 130754-15-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: ethyl 2-fluoro-2-(3-methoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-fluoro-2-(3-methoxyphenyl)acetate(130754-15-3)
• EPA Substance Registry System: ethyl 2-fluoro-2-(3-methoxyphenyl)acetate(130754-15-3)

Safety Data

• Hazardous Substances Data: 130754-15-3(Hazardous Substances Data)

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 
• 401-56-9 ethyl chlorofluoroacetate 
• 79421-99-1 tris(3-methoxyphenyl)-1,3,5,2,4,6-trioxatriborinane 
• 100701-49-3 3-ethoxy-2-fluoro-3-oxopropionic acid 
• 401-55-8 ethyl bromofluoroacetate 
• 766-85-8 3-methoxy-1-iodobenzene 
• 53392-03-3 (3-methoxyphenyl)triethoxysilane 
• 10365-98-7 3-methoxyphenylboronic acid 
• 1798-09-0 m-methoxyphenylacetic acid 
• 35553-92-5 ETHYL 3-METHOXYPHENYLACETATE 

Relevant articles and documents

Nickel-Catalyzed Cross-Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides

A combinatorial nickel-catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent ethyl chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process.

Copper-Mediated Synthesis of Monofluoro Aryl Acetates via Decarboxylative Cross-Coupling

We report the Cu-promoted oxidative cross-coupling of α-fluoromalonate half-esters and aryl boron reagents to deliver mono-fluoro α-aryl acetates under mild conditions (in air at room temperature). The reaction uses a simple, readily available monofluorinated building block to generate arylated compounds with functional groups that are not easily tolerated by existing methods, such as aryl bromides, iodides, pyridines, and pyrimidines.

Nickel-Catalyzed Monofluoroalkylation of Arylsilanes via Hiyama Cross-Coupling

The first example of nickel-catalyzed monofluoroalkylation of arylsilanes has been developed with readily available fluoroalkyl halides. This novel transformation has demonstrated high reactivity, broad substrate scope, excellent functional group tolerance, and mild reaction conditions. The selective activation of a relatively inert C-Si bond for slow release of aryl carbanion is the key reason for reducing the amount of arylmetal species, which makes this method more promising for fluorine-containing modification of complex bioactive molecules. Mechanistic investigations indicate that a free fluoroalkyl radical is involved in this catalytic cycle.