130767-22-5

Upstream product

• 52548-14-8 2-iodoyl-5-methylbenzoic acid 
• 103440-52-4 methyl 2-iodo-5-methylbenzoate 
• 125131-09-1 Methyl 2-<(Z)-bis-1,4-(tert-butyldimethylsiloxy)-2-buten-2-yl>-5-methylbenzoate 
• 125131-10-4 (Z)-(2-Hydroxyethyliden-1-yl)-7-methylisochroman-1-one 
• 125131-11-5 (Z)-(2-Bromoethyliden-1-yl)-7-methylisochroman-1-one 
• 130767-21-4 (4Z)-7-Methyl-4-(2-p-toluenesulphonylethyliden-1-yl)-isochroman-1-one 
• 78-84-2 isobutyraldehyde 

Relevant academic research and scientific papers

A NEW APPROACH TO 1,7-DIOXASPIROUNDEC-4-ENES VIA METALLATED ALLENOL ETHERS. SYNTHESIS OF LACRIMIN A.

Key steps in the first total synthesis of Lacrimin A (2) include (a) the use of methoxyallene as an enone-1,3-dianion equivalent; (b) the use of a new copper-catalysed migratory insertion reaction to construct a tri-substituted alkene stereoselectively; and (c) the use of a Pd(0)-catalysed coupling reaction to generate an isochromanone ring.