1307683-82-4Relevant academic research and scientific papers
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs
Guandalini,Martini,Di Cesare Mannelli,Dei,Manetti,Scapecchi,Teodori,Ghelardini,Romanelli
, p. 1936 - 1939 (2012/04/04)
A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
SUBSTITUTED AMINO HETEROCYCLES USEFUL AS HIV ANTAGONISTS
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, (2011/06/16)
The present invention relates to compounds of Formula (I): wherein the variables are as defined in the specification. The present invention further relates to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular for the treatment or prevention of chemokine-mediated disorders such as HIV infection.
