54881-13-9

Basic information

• Product Name: 1-Benzylazetidin-3-ol
• Synonyms: N-BENZYL-3-HYDROXYAZETIDINE;1-BENZYLAZETIDINE-3-OL;1-BENZYL AZETIDINE-3-OL 98%;1-Benzyl-3-hydroxyazetidine;1-Benzylazetidin-3-ol;3-Azetidinol, 1-(phenylmethyl)-;1-Benzyl-3-azetidinol;1-Benzyl-3-hydroxyazetidi...
• CAS NO: 54881-13-9
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Product Categories: Heterocyclic Compounds
• Mol File: 54881-13-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 64-65 °C
• Boiling Point: 259.17 °C at 760 mmHg
• Flash Point: 105.864 °C
• Appearance: /
• Density: 1.189 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 14.33±0.20(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-Benzylazetidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzylazetidin-3-ol(54881-13-9)
• EPA Substance Registry System: 1-Benzylazetidin-3-ol(54881-13-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 54881-13-9(Hazardous Substances Data)

Usage

General Description

1-Benzylazetidin-3-ol, also known as (3R)-1-benzylazetidin-3-ol, is a chemical compound with the molecular formula C11H15NO. It is an azetidinol compound, which is a class of four-membered heterocycles with a nitrogen atom. 1-Benzylazetidin-3-ol is commonly used as a building block in organic synthesis and pharmaceutical research. It has been found to exhibit potential biological activities, including as a cholinesterase inhibitor and a potential anti-Alzheimer's agent. The compound's unique structure and pharmacological properties make it a promising candidate for further study and potential therapeutic applications.

InChI:InChI=1/C10H13NO/c12-10-7-11(8-10)6-9-4-2-1-3-5-9/h1-5,10,12H,6-8H2

Upstream product

• 111043-42-6 N-benzyl-3-(trimethylsilyloxy)azetidine 
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• 111043-32-4 1-benzyl-(3-chloro-2-trimethylsilyloxypropyl)-amine 
• 75605-52-6 N-benzyl-3-amino-1-chloropropan-2-ol 
• 80236-09-5 N-benzyl-1-(oxiran-2-yl)methanamine 

Downstream Products

• 56862-39-6 3-(N-benzyl-N-methyl)amino-2-chloro-1-propene 
• 1307683-82-4 N-(1-benzylazetidin-3-yl)acetamide 
• 1365212-21-0 C₁₃H₁₈N₂O 
• 223382-13-6 1-benzylazetidine-3-ol hydrochloride 
• 141699-55-0 tert-butyl 3-hydroxyazetidine-1-carboxylate 
• 18621-18-6 azetion-3-ol hydrochloride 
• 878391-51-6 1-benzyl-3-acetylthio-azetidine 
• 67160-49-0 1-benzyl-3-methanesulfonyloxyazetidine 
• 685891-48-9 1-benzyl-3-chloroazetidine 
• 858940-94-0 N-benzyl-3-bromoazetidine 
• 156303-83-2 1-benzyl-3-azetidinone 

Relevant articles and documents

Preparation method of 2-[1-(ethyl sulfonyl)-3-azacyclic butyl] acetonitrile

The invention relates to the technical field of medical chemistry, and particularly relates to a preparation method of a baricotinib tetratomic ring intermediate, and also provides green oxidizing reaction performed in a micro-channel reactor. According to the method, the raw materials in the technical route are easily obtained; the method is economic, green, environmentally friendly and suitablefor industrial production.

ACID ADDITION SALTS OF SYNTHETIC INTERMEDIATES FOR CARBAPENEM ANTIBIOTICS AND PROCESSES FOR PREPARING THE SAME

The present invention provides a process for preparing an acid addition salt of a synthetic intermediate for carbapenem antibiotics and a novel acid addition salt of a synthetic intermediate for carbapenem antibiotics obtained from the process. The present invention also provides a process for preparing a carbapenem antibiotic using the acid addition salt. According to the process of the present invention, an acid addition salt of a synthetic intermediate for carbapenem antibiotics can be prepared in a high yield and high purity, without conducting column chromatography. Thus, the process of the present invention can be applied to mass production with an industrial scale. Furthermore, since the acid addition salts have solid forms, they are easy to handle and keep in a manufacturing site.

PREPARATION OF PYRIDONECARBOXYLIC ACID ANTIBACTERIALS

A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.