1307905-23-2

Upstream product

• 1117-96-0 Diazoethan 
• 1040285-21-9 (E)-4-(2-phenylvinyl)-2-(trichloromethyl)-4,5-dihydro-1,3-oxazole 
• 1307904-92-2 2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester 
• 62499-97-2 (Z)-1,4-dihydroxy-1-phenylbut-2-ene 
• 29021-82-7 1-phenylbut-2-yne-1,4-diol 
• 74141-11-0 trans-1-Phenyl-2-buten-1,4-diol 
• 100-52-7 benzaldehyde 
• 132803-75-9 (+/-)-(3E)-2-amino-4-phenylbut-3-en-1-ol 
• 312521-54-3 (E)-2-t-butoxycarbonylamido-4-phenyl-3-butene-1-ol 

Relevant academic research and scientific papers

Lewis acid catalyzed intramolecular allylic substitution of bis(trichloroacetimidates): A versatile approach to racemic unsaturated amino acids

Lewis acid catalyzed cyclization of trichloroacetimidates derived from 1,4-butenediols and 1,5-butenediols was achieved to give 4-vinyl oxazolines and 4-vinyloxazines in good to excellent yields. The cyclization products were transformed to protected unsaturated α- and β-amino acids, thus demonstrating the novel approach to access these important classes of compounds. Lewis acid catalyzed cyclization of allylic bis(trichloroacetimidates) (n = 1, 2) provides 4-vinyloxazolines and 4-vinyloxazines. The products of cyclization weredemonstrated to be versatile intermediates for the synthesis of unsaturated α- and β-amino acids. Copyright