132803-75-9

Upstream product

• 62499-97-2 (Z)-1,4-dihydroxy-1-phenylbut-2-ene 
• 29021-82-7 1-phenylbut-2-yne-1,4-diol 
• 74141-11-0 trans-1-Phenyl-2-buten-1,4-diol 
• 100-52-7 benzaldehyde 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 1620206-11-2 C₁₂H₁₂Cl₃NO 
• 1620206-12-3 (E)-N-(1-bromo-4-phenylbut-3-en-2-yl)-2,2,2-trichloroacetamide 
• 1307904-92-2 2,2,2-trichloroacetimidic acid (Z)-1-phenyl-4-(2,2,2-trichloroacetimidoyloxy)but-2-enyl ester 
• 1040285-21-9 (E)-4-(2-phenylvinyl)-2-(trichloromethyl)-4,5-dihydro-1,3-oxazole 
• 89368-01-4 2-styryloxirane 
• 14371-10-9 (E)-3-phenylpropenal 
• 132803-71-5 (E)-2-azido-4-phenyl-3-buten-1-ol 

Downstream Products

• 1307905-23-2 methyl (E)-2-[(tert-butoxycarbonyl)amino]-4-phenylbut-3-enoate 
• 1402941-90-5 C₁₅H₁₇NO₃ 
• 132682-25-8 (E)-(R)-(+)-3-(2'-phenyl-1'-ethylenyl)-2-oxazolidinone 
• 312521-45-2 (4S)-4-[(E)-2-phenylethenyl]-1,3-oxazolidin-2-one 
• 312521-56-5 N-[1-acetoxy-4-phenyl-3-butene-2-yl] 4,5,6,8-tetra-O-acetyl-3,7-anhydro-2-deoxy-D-glycero-D-gulo-octonoyl amide 
• 312521-55-4 (E)-1-acetoxy-2-t-butoxycarbonylamido-4-phenyl-3-butene 

Relevant academic research and scientific papers

N-bromoacetamide-mediated domino cyclization and elimination of homoallylic trichloroacetimidates: A novel approach toward the synthesis of 1-bromo-2-amino-3-butene derivatives

A practical synthesis of 1-bromo-2-amino-3-butene derivatives from homoallylic trichloroacetimidates was reported. Simply heating the mixture of substrates and N-bromoacetamide in DMF at 90 °C would give the desired products in moderate to excellent yield

Lewis acid catalyzed intramolecular allylic substitution of bis(trichloroacetimidates): A versatile approach to racemic unsaturated amino acids

Lewis acid catalyzed cyclization of trichloroacetimidates derived from 1,4-butenediols and 1,5-butenediols was achieved to give 4-vinyl oxazolines and 4-vinyloxazines in good to excellent yields. The cyclization products were transformed to protected unsaturated α- and β-amino acids, thus demonstrating the novel approach to access these important classes of compounds. Lewis acid catalyzed cyclization of allylic bis(trichloroacetimidates) (n = 1, 2) provides 4-vinyloxazolines and 4-vinyloxazines. The products of cyclization weredemonstrated to be versatile intermediates for the synthesis of unsaturated α- and β-amino acids. Copyright

Flexible synthesis and biological evaluation of novel 5-deoxyadenophorine analogues

Adenophorine and its 5-deoxy analogue have been identified as natural iminosugars with efficient glycosidase inhibitory effects. The syntheses and biological evaluation of two new series of 5-deoxyadenophorine analogues in their racemic form are reported.

Indium-mediated stereoselective synthesis of truncated, 6- and 7-carbon sialic acids

Several 6- and 7-carbon sialic acid derivatives were synthesized, without tedious protecting group manipulations, in high overall yields. A key step of the synthesis was the chain extension of suitable α-amino aldehyde derivatives by an indium-mediated addition of ethyl 2-(bromomethyl)acrylate. Under acidic reaction conditions, the corresponding extended enoates were obtained with high trans-stereoselectivity. Ozonolysis furnished the desired 4-acylamino-substituted hexulosonic and heptulosonic acids in free form for biochemical studies.