130791-17-2

Upstream product

• 88517-61-7 (5S)-1-methyl-5-isopropyl-2,4-dioxopyrrolidine 
• 98-88-4 benzoyl chloride 
• 42417-65-2 Z-MeVal-OH 
• 115084-81-6 1-methyl-5-isopropylpyrrolidine-2,4-dione 
• 100-52-7 benzaldehyde 
• 109826-81-5 5-Isopropyl-4-methoxy-1-methyl-1,5-dihydro-pyrrol-2-one 
• 88517-64-0 3-(Hydroxy-phenyl-methyl)-5-isopropyl-4-methoxy-1-methyl-1,5-dihydro-pyrrol-2-one 
• 88517-68-4 3-Benzoyl-5-isopropyl-4-methoxy-1-methyl-1,5-dihydro-pyrrol-2-one 
• 88517-58-2 (S)-2-[(2-Ethoxycarbonyl-acetyl)-methyl-amino]-3-methyl-butyric acid methyl ester 
• 3339-44-4 methyl N-methyl-L-valinate hydrochloride 

Relevant academic research and scientific papers

Acetylation of Pyrrolidine-2,4-diones: A Synthesis of 3-Acyltetramic Acids. X-Ray Molecular Structure of 3--5-isopropyl-1-methylpyrrolidine-2,4-dione

Pyrrolidine-2,4-diones, prepared from the corresponding α-amino acid esters by condensation with ethoxycarbonylacetic acid, Dieckmann cyclisation, and hydrolysis-decarboxylation, are acylated at C-3 by the acid chlorides of saturated, unsaturated, and are

DIRECTED METALLATION OF TETRAMIC ACIDS: A NEW SYNTHESIS OF 3-ACYL TETRAMIC ACIDS

3-Acyl tetramic acids have been prepared by directed metallation at C-3 of the 4-O-methyl ethers of pyrrolidine-2,4-diones, reaction of the vinyl-lithium derivative with aldehydes, and oxidation and hydrolysis of the adducts.

ACYLATION OF PYRROLIDINE-2,4-DIONES : BORON DIFLUORIDE COMPLEXES OF 3-ACYL TETRAMIC ACIDS

Boron difluoride complexes of 3-acyl tetramic acids have been isolated from acylation of pyrrolidine-2,4-diones with acid chlorides and boron trifluoride-etherate, or prepared from 3-acyl tetramic acids.Their deprotonation has been studied.