130830-60-3

Basic information

• Product Name: (2R, 4R)-4-(TOLUENE-4-SULFONYLOXY)-1-[BENZYLOXYCARBONYL]-PYRROLIDINE-2-ETHYLCARBOXYLATE
• Synonyms: (2R, 4R)-4-(TOLUENE-4-SULFONYLOXY)-1-[BENZYLOXYCARBONYL]-PYRROLIDINE-2-ETHYLCARBOXYLATE
• CAS NO: 130830-60-3
• Molecular Formula: C₂₂H₂₅NO₇S
• Molecular Weight: 447.5
• Mol File: 130830-60-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R, 4R)-4-(TOLUENE-4-SULFONYLOXY)-1-[BENZYLOXYCARBONYL]-PYRROLIDINE-2-ETHYLCARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R, 4R)-4-(TOLUENE-4-SULFONYLOXY)-1-[BENZYLOXYCARBONYL]-PYRROLIDINE-2-ETHYLCARBOXYLATE(130830-60-3)
• EPA Substance Registry System: (2R, 4R)-4-(TOLUENE-4-SULFONYLOXY)-1-[BENZYLOXYCARBONYL]-PYRROLIDINE-2-ETHYLCARBOXYLATE(130830-60-3)

Safety Data

• Hazardous Substances Data: 130830-60-3(Hazardous Substances Data)

Usage

General Description

The chemical (2R, 4R)-4-(toluene-4-sulfonyloxy)-1-[benzyloxycarbonyl]-pyrrolidine-2-ethylcarboxylate is a compound with a complex molecular structure. It contains a pyrrolidine ring with a benzyloxycarbonyl group attached to the nitrogen atom, as well as an ethyl ester at the carboxylic acid group. Additionally, there is a toluene sulfonyloxy group attached to the 4-position on the pyrrolidine ring. (2R, 4R)-4-(TOLUENE-4-SULFONYLOXY)-1-[BENZYLOXYCARBONYL]-PYRROLIDINE-2-ETHYLCARBOXYLATE may have potential applications in organic synthesis and medicinal chemistry due to its unique structural features and functional groups. However, it is important to handle and use this compound with caution due to its potential reactivity and toxicity.

Upstream product

• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 103667-57-8 (2S,4R)-ethyl N¹-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 130830-65-8 N-(benzyloxycarbonyl)-cis-4-cyano-L-proline ethyl ester 
• 586396-26-1 cis-N-(benzyloxycarbonyl)-4-carboxy-L-proline methyl ester 
• 1430105-81-9 C₁₅H₁₉NO₅ 
• 1446655-22-6 C₂₁H₂₃NO₄ 
• 1446655-24-8 C₂₈H₂₉NO₄ 
• 1446653-56-0 (2S,4S)-4-(benzyloxymethyl)-1-(2,2-diphenylacetyl)pyrrolidine-2-carboxylic acid 
• 1446655-26-0 C₂₃H₂₄N₂O₆ 
• 1446655-28-2 C₂₃H₂₂N₂O₅ 
• 1446655-30-6 C₁₅H₁₆N₂O₃ 
• 1446655-32-8 C₂₉H₂₆N₂O₄ 
• 1446653-58-2 (2S,4S)-1-(2,2-diphenylacetyl)-4-(5-phenyloxazol-2-yl)pyrrolidine-2-carboxylic acid 
• 1446655-40-8 C₂₂H₂₅NO₆S 
• 1446655-34-0 C₂₉H₃₁NO₃S 
• 1446655-38-4 C₂₈H₂₉NO₃S 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS

The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Conformationally Defined Neurotransmitter Analogues. Selective Inhibition of Glutamate Uptake by One Pyrrolidine-2,4-dicarboxylate Diastereomer

In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of neurotransmission, rigid analogues containing an embedded glutamate moiety have been prepared.These "conformer mimics", the pyrrolidine-2,4-dicarboxylates 4, 7, 11, and 14, were synthesized from commercially available trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline, and then were tested for their ability to inhibit the high-affinity transport of -L-glutamate into synaptosomes and to block the binding of radioligands to the NMDA (N-methyl-D-aspartate), KA (kainate), and QA (quisqualate) glutamate neurotransmitter receptor sites.While none of the four analogues binds effectively to the excitatory receptors, the L-trans-isomer 7 is a potent and selective competitive inhibitor of L-glutamate transport.These results delineate a specific structural/conformational preference for binding to the uptake system that is distinct from that required for binding to the NMDA, KA, and QA receptors.