130830-61-4

Basic information

• Product Name: N-(benzyloxycarbonyl)-cis-4-(tosyloxy)-L-proline ethyl ester
• Synonyms: N-(benzyloxycarbonyl)-cis-4-(tosyloxy)-L-proline ethyl ester
• CAS NO: 130830-61-4
• Molecular Weight: 447.509
• Mol File: 130830-61-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(benzyloxycarbonyl)-cis-4-(tosyloxy)-L-proline ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzyloxycarbonyl)-cis-4-(tosyloxy)-L-proline ethyl ester(130830-61-4)
• EPA Substance Registry System: N-(benzyloxycarbonyl)-cis-4-(tosyloxy)-L-proline ethyl ester(130830-61-4)

Safety Data

• Hazardous Substances Data: 130830-61-4(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 64187-47-9 1-benzyloxycarbonyl-4-keto-L-proline 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 13504-86-4 (2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline 
• 130930-26-6 N-(benzyloxycarbonyl)-cis-4-hydroxy-L-proline ethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 130830-66-9 N-(benzyloxycarbonyl)-trans-4-cyano-L-proline ethyl ester 
• 64769-66-0 (2S,4R)-L-proline-4-carboxylic acid 
• 130830-74-9 N-(benzyloxycarbonyl)-trans-4-carboxy-L-proline 
• 130830-70-5 N-(benzyloxycarbonyl)-trans-4-carboxy-L-proline dimethyl ester 
• 130830-81-8 Mosher amide of trans-4-carboxy-L-proline dimethyl ester 

Relevant articles and documents

Conformationally Defined Neurotransmitter Analogues. Selective Inhibition of Glutamate Uptake by One Pyrrolidine-2,4-dicarboxylate Diastereomer

In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of neurotransmission, rigid analogues containing an embedded glutamate moiety have been prepared.These "conformer mimics", the pyrrolidine-2,4-dicarboxylates 4, 7, 11, and 14, were synthesized from commercially available trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline, and then were tested for their ability to inhibit the high-affinity transport of -L-glutamate into synaptosomes and to block the binding of radioligands to the NMDA (N-methyl-D-aspartate), KA (kainate), and QA (quisqualate) glutamate neurotransmitter receptor sites.While none of the four analogues binds effectively to the excitatory receptors, the L-trans-isomer 7 is a potent and selective competitive inhibitor of L-glutamate transport.These results delineate a specific structural/conformational preference for binding to the uptake system that is distinct from that required for binding to the NMDA, KA, and QA receptors.