130836-58-7

Upstream product

• 69778-83-2 4-methoxy-3-pyrrolin-2-one 
• 100-39-0 benzyl bromide 
• 15028-44-1 DL-phenylalanine methyl ester 
• 73818-55-0 Bestmann ylide 

Downstream Products

• 130836-63-4 (S)-5-Benzyl-5-((E)-(S)-1-hydroxy-but-2-enyl)-4-methoxy-1,5-dihydro-pyrrol-2-one 
• 130836-60-1 (5R,7R,7aR)-7a-Benzyl-5-hydroxy-1-methoxy-7-methyl-5,6,7,7a-tetrahydro-pyrrolizin-3-one 
• 130836-60-1 (5R,7S,7aR)-7a-Benzyl-5-hydroxy-1-methoxy-7-methyl-5,6,7,7a-tetrahydro-pyrrolizin-3-one 
• 130836-56-5 5-benzyl-1-methyl-4-O-methyl tetramate 
• 130836-68-9 5-benzyl-1,5-dimethyl-4-O-methyl tetramate 
• 130836-64-5 5-Benzyl-5-((E)-but-2-enoyl)-4-methoxy-1,5-dihydro-pyrrol-2-one 
• 130836-84-9 5-Benzyl-3-[1-hydroxy-but-(E)-ylidene]-1,5-dimethyl-pyrrolidine-2,4-dione 
• 130836-81-6 5-Benzyl-4-methoxy-1,5-dimethyl-3-((E)-pent-2-enoyl)-1,5-dihydro-pyrrol-2-one 
• 130836-82-7 5-Benzyl-3-((2E,4E)-hexa-2,4-dienoyl)-4-methoxy-1,5-dimethyl-1,5-dihydro-pyrrol-2-one 
• 130836-80-5 5-Benzyl-3-butyryl-4-methoxy-1,5-dimethyl-1,5-dihydro-pyrrol-2-one 
• 130836-73-6 5-Benzyl-3-(1-hydroxy-butyl)-4-methoxy-1,5-dimethyl-1,5-dihydro-pyrrol-2-one 
• 130836-74-7 5-Benzyl-3-((E)-1-hydroxy-pent-2-enyl)-4-methoxy-1,5-dimethyl-1,5-dihydro-pyrrol-2-one 
• 130836-75-8 5-Benzyl-3-((2E,4E)-1-hydroxy-hexa-2,4-dienyl)-4-methoxy-1,5-dimethyl-1,5-dihydro-pyrrol-2-one 
• 130836-61-2 (1R,7aR)-7a-Benzyl-7-methoxy-1-methyl-1,7a-dihydro-2H-pyrrolizine-3,5-dione 

Relevant academic research and scientific papers

Domino syntheses of five-, six- and seven-membered O-, N- and S-heterocycles from α-, β- and γ-substituted carboxylic esters

By a one-pot procedure, tetronic acids, tetronates, coumarins, benzoxepinones and their N- and S-analogues are readily accessible from keteneylidene(triphenyl)phosphorane 2 and carboxylic esters bearing OH, NHR or SH groups in an α-, β- or γ-position by an addition/Wittig olefination/(Claisen rearrangement) sequence. This cascade can be controlled by temperature variation. Extension of this procedure by a further addition step yielding annulated bisheterocycles such as the furoquinolone 28 is possible in some cases.

New Protocols for the Synthesis of Substituted 4-O-Methyl Tetramates

The deprotonation behaviour of 4-methoxypyrrol-2(5H)-ones (4-O-methyl tetramates) is defined and exploited to provide methods for the synthesis of methyl tetramates variously substituted at N-1, C-5, and C-3.