69778-83-2Relevant articles and documents
SYNTHESIS OF PUKELEIMIDE A
James, Gwyn D.,Pattenden, Gerald,Mills, Stuart D.
, p. 3617 - 3620 (1985)
A total synthesis of the 5-ylidenepyrrole-2-one pukeleimide A (3), a constituent of the marine blue-green alga Lyngbya majuscula,is described.
Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials
Conroy, Trent,Guo, Jin T.,Elias, Nabiha,Cergol, Katie M.,Gut, Jiri,Legac, Jennifer,Khatoon, Lubna,Liu, Yang,McGowan, Sheena,Rosenthal, Philip J.,Hunt, Nicholas H.,Payne, Richard J.
supporting information, p. 10557 - 10563 (2015/02/19)
Analogues of the natural product gallinamide A were prepared to elucidate novel inhibitors of the falcipain cysteine proteases. Analogues exhibited potent inhibition of falcipain-2 (FP-2) and falcipain-3 (FP-3) and of the development of Plasmodium falciparum in vitro. Several compounds were equipotent to chloroquine as inhibitors of the 3D7 strain of P. falciparum and maintained potent activity against the chloroquine-resistant Dd2 parasite. These compounds serve as promising leads for the development of novel antimalarial agents.
Direct-type vinylogous Mukaiyama-Michael addition reactions involving pyrrolinone donors
Sartori, Andrea,Curti, Claudio,Battistini, Lucia,Burreddu, Paola,Rassu, Gloria,Pelosi, Giorgio,Casiraghi, Giovanni,Zanardi, Franca
experimental part, p. 11697 - 11705 (2009/04/06)
The direct Mukaiyama-Michael addition of vinylogous tetramate donors to a number of different Michael acceptors has been easily executed, by employing the TMSOTf/Et3N mixture as soft Lewis acid/base promoter agent. Richly functionalized, highly
