130867-57-1

Basic information

• Product Name: 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine
• Synonyms: 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine
• CAS NO: 130867-57-1
• Molecular Weight: 616.668
• Mol File: 130867-57-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine(130867-57-1)
• EPA Substance Registry System: 5’-O-dimethoxytrityl-3’-O-methoxyacetylthymidine(130867-57-1)

Safety Data

• Hazardous Substances Data: 130867-57-1(Hazardous Substances Data)

Upstream product

• 38870-89-2 Methoxyacetyl chloride 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 19500-95-9 Methoxyacetic anhydride 

Downstream Products

• 133510-69-7 Methoxy-acetic acid (2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-((3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxymethoxymethyl)-tetrahydro-furan-3-yl ester 
• 133510-55-1 C₄₃H₄₆N₄O₁₆ 
• 133510-51-7 C₄₅H₅₀N₄O₁₄ 
• 133510-64-2 (S)-3-[(2R,3S,5R)-5-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-methoxy-acetoxy)-tetrahydro-furan-2-ylmethoxymethoxy]-2-benzyloxycarbonylamino-propionic acid benzyl ester 
• 133510-66-4 Methoxy-acetic acid (2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(bis-benzyloxy-phosphoryloxymethoxymethyl)-tetrahydro-furan-3-yl ester 
• 133527-00-1 5'-O-levulinoyl-3'-O-(4-pentenyloxymethyl)-N³-benzoyl-thymidine 
• 133510-53-9 5'-O-levulinoyl-3'-O-methylthiomethyl-N³-benzoyl-thymidine 
• 133510-61-9 5'-O-methylthiomethyl-3'-O-methoxyacetyl-N³-benzoyl-thymidine 
• 133510-54-0 3-Benzoyl-1-((2R,4S,5R)-5-hydroxymethyl-4-pent-4-enyloxymethoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 133510-52-8 3-Benzoyl-1-((2R,4S,5R)-5-hydroxymethyl-4-methylsulfanylmethoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 133510-59-5 C₆₁H₆₄N₆O₂₂ 
• 130887-31-9 C₆₅H₇₁N₆O₁₅P 
• 130867-64-0 C₅₉H₅₈N₄O₁₆ 
• 130867-68-4 C₅₆H₅₄N₄O₁₄ 

Relevant articles and documents

LINKER COMPOUNDS

Linker compounds, methods of making them, and methods of using them as linking agents for oligonucleotides and other chemical and biological substances are described. Embodiments of linker compounds are configured or selected to exhibit higher stability t

An alternative route to the preparation of (3' → 5') methylene acetal linked di- and trinucleosides

Reaction of deoxynucleoside 3'-O-(methylthiomethyl) acetals 1 with N-iodosuccinimide (NlS) and dibutyl phosphate furnished the corresponding 3'-O-(dibutoxyphosphoryloxy)methyl acetals 6. Condensation of the latter with appropriately protected deoxynucleoside acceptors 3, in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf), afforded in most cases the (3' → 5') methylene acetal linked d(B(1Λ) B2) dimers 4. In addition, TMSOTf-promoted coupling of donor 6 (B1 = C(Bz)) with 3'-O-(methylthiomethyl)thymidine (8) yielded dimer 9. Reaction of 9 with NIS and dibutyl phosphate gave dimer 10, which was applied successfully in the TMSOTf-assisted fusion with acceptors 3 (B2 = C(Bz) and A(Bz)), to afford the corresponding trimers d(C(Λ)T(Λ)C) 11 and d(C(Λ)T(Λ)A) 12.

SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING THYMIDINES LINKED VIA AN INTERNUCLEOSIDIC-(3'-5')-METHYLENE BOND

Condensation of N3-benzoyl-5'-O-dimethoxytrityl-3'-O-(4-penten-1-oxomethyl)-thymidine with N3-benzoyl-3'-O-methoxyacetyl-thymidine, in the presence of N-iodosuccinimide, afforded a fully-protected thymidine dimer having an internucle