130878-18-1

Basic information

• Product Name: (2S,3S)1-benzyloxy-4-chloro-2,3-(O-isopropylidene)butane-2,3-diol
• Synonyms: (2S,3S)1-benzyloxy-4-chloro-2,3-(O-isopropylidene)butane-2,3-diol
• CAS NO: 130878-18-1
• Molecular Weight: 270.756
• Mol File: 130878-18-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2S,3S)1-benzyloxy-4-chloro-2,3-(O-isopropylidene)butane-2,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)1-benzyloxy-4-chloro-2,3-(O-isopropylidene)butane-2,3-diol(130878-18-1)
• EPA Substance Registry System: (2S,3S)1-benzyloxy-4-chloro-2,3-(O-isopropylidene)butane-2,3-diol(130878-18-1)

Safety Data

• Hazardous Substances Data: 130878-18-1(Hazardous Substances Data)

Upstream product

• 78469-77-9 (4S,5S)-4-benzyloxymethyl-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane 
• 100-44-7 benzyl chloride 
• 50622-09-8 2,3-O-isopropylidene-L-threitol 
• 59779-75-8 diethyl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate 

Downstream Products

• 109613-59-4 (S)-1-(benzyloxy)but-3-en-2-ol 
• 114826-50-5 (4R,5S)-2,2-dimethyl-4-iodomethyl-5-benzyloxymethyl-1,3-dioxolane 
• 85428-24-6 (R)-4-benzyloxy-3-hydroxy-1-butyne 

Relevant articles and documents

Mild and efficient palladium(II)-catalyzed racemization of allenes

Allenes undergo racemization in the presence of catalytic amounts of Pd(OAc)2/LiBr under mild conditions; the reaction proceeds via a bromopalladation-debromopalladation sequence and tolerates various functional groups.

Reductive Cleavage Reaction of γ-Functionalized α,β-Unsaturated Esters and Halomethyls Mediated with Magnesium in Methanol

Reductive cleavage of various types of C-O and C-N bonds tethered to α,β-unsaturated esters and halomethyls was mediated with magnesium in methanol, which provided a facile method for the synthesis of δ-hydroxy or δ-amino β,γ-unsaturated esters and allylic alcohols.Regardless of the geometry (E or Z) of the α,β-unsaturated esters, 1a-b, 5a-c, 11, 13, and 23, the cleavage product obtained was exclusively the E isomer of the corresponding deconjugated hydroxy and amino esters.The steric bias and ring strain of 15, 17, and 21 gave rise to a product mixture of E and Z isomers.

Synthesis of a novel four-carbon chiron - (R)-1-t-butyldimethylsilyl-3,4-epoxy-but-1-yne

A simple and efficient synthesis of the novel chiron-(R)-1-TBDMS-3,4-epoxy-but-1-yne has been developed starting from a derivative of (R,R)-(-)-tartaric acid. A new stereoselective bromination reaction of an O-silyl ether with BBr3 is also described.