1308813-92-4

Basic information

• Product Name: C₃₇H₄₀N₄O₁₁S
• CAS NO: 1308813-92-4
• Molecular Weight: 748.811
• Mol File: 1308813-92-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₀N₄O₁₁S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₀N₄O₁₁S(1308813-92-4)
• EPA Substance Registry System: C₃₇H₄₀N₄O₁₁S(1308813-92-4)

Safety Data

• Hazardous Substances Data: 1308813-92-4(Hazardous Substances Data)

Upstream product

• 518-28-5 podofilox 
• 477-51-0 deoxypodophyllotoxin 
• 5241-66-7 (R)-N-(tert-butoxycarbonyl)methionine 
• 6269-89-2 1-(4-Nitrophenyl)piperazine 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 3590-93-0 4'-demethyl-4-deoxypodophyllotoxin 

Relevant articles and documents

Synthesis and biological evaluation of derivatives of 4- deoxypodophyllotoxin as antitumor agents

In an attempt to generate compounds with superior bioactivity and reduced toxicity, a series of derivatives of deoxypodophyllotoxin were synthesized by reacting 4′-demethyl-4-deoxypodophyllotoxin with substituted piperazines or their amino acid amides. The cytotoxic activity of these compounds against three human cancer cell lines was evaluated. We found that p- nitrophenylpiperazine substitution (Compound 8b) led to an increase in the potency of the compound. Compound 8b exhibited the most potent cytotoxicity against A-549, HeLa and SiHa cells (IC50 values were 0.102, 0.180 and 0.0195 μM, respectively). In addition, flow cytometric analysis showed that 8b induced cell cycle arrest in the G1 phase accompanied by apoptosis in A-549 cells.