1308889-57-7

Basic information

• Product Name: N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide
• Synonyms: N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide
• CAS NO: 1308889-57-7
• Molecular Weight: 494.588
• Mol File: 1308889-57-7.mol

Chemical Properties

• CAS DataBase Reference: N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide(1308889-57-7)
• EPA Substance Registry System: N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide(1308889-57-7)

Safety Data

• Hazardous Substances Data: 1308889-57-7(Hazardous Substances Data)

Upstream product

• 3179-63-3 3-Dimethylamino-1-propanol 
• 92194-92-8 4-(chlorocarbonyl)-2-(3-methylbut-2-en-1-yl)phenyl acetate 
• 1308889-55-5 4-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate 
• 1308889-53-3 benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate 
• 1083312-78-0 benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate 

Relevant articles and documents

Engineering an antibiotic to fight cancer: Optimization of the novobiocin scaffold to produce anti-proliferative agents

Development of the DNA gyrase inhibitor, novobiocin, into a selective Hsp90 inhibitor was accomplished through structural modifications to the amide side chain, coumarin ring, and sugar moiety. These species exhibit ?700- fold improved anti-proliferative activity versus the natural product as evaluated by cellular efficacies against breast, colon, prostate, lung, and other cancer cell lines. Utilization of structure- activity relationships established for three novobiocin synthons produced optimized scaffolds, which manifest midnanomolar activity against a panel of cancer cell lines and serve as lead compounds that manifest their activities through Hsp90 inhibition.