N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide

Base Information

• Chemical Name: N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide
• CAS No.: 1308889-57-7
• Molecular Formula: C₂₈H₃₄N₂O₆
• Molecular Weight: 494.588
• Mol file: 1308889-57-7.mol

Synonyms:N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide

Chemical Property of N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide

There total 5 articles about N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate (1308889-55-5) → N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide (1308889-57-7)

Guidance literature:

With triethylamine; In methanol; at 20 ℃;

DOI:10.1021/jm200148p

Reference yield:

benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1083312-78-0) → N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide (1308889-57-7)

Guidance literature:

Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2: palladium on carbon; hydrogen / tetrahydrofuran

3: pyridine; dichloromethane / 2 h / 20 °C

4: triethylamine / methanol / 20 °C

With di-isopropyl azodicarboxylate; palladium on carbon; hydrogen; triethylamine; triphenylphosphine; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1: Mitsunobu reaction;

DOI:10.1021/jm200148p

Reference yield:

benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1308889-53-3) → N-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-yl)-4-hydroxy-3-(3-methylbut-2-enyl)benzamide (1308889-57-7)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on carbon; hydrogen / tetrahydrofuran

2: pyridine; dichloromethane / 2 h / 20 °C

3: triethylamine / methanol / 20 °C

With palladium on carbon; hydrogen; triethylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane;

DOI:10.1021/jm200148p

upstream raw materials:

benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

benzyl 7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

4-(7-(3-(dimethylamino)propoxy)-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

4-(chlorocarbonyl)-2-(3-methylbut-2-en-1-yl)phenyl acetate