1309042-24-7

Basic information

• Product Name: (L)-2-(pyridin-4-yl)-N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)-1H-benzimidazole-4-carboxamide
• Synonyms: (L)-2-(pyridin-4-yl)-N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)-1H-benzimidazole-4-carboxamide
• CAS NO: 1309042-24-7
• Molecular Weight: 433.423
• Mol File: 1309042-24-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (L)-2-(pyridin-4-yl)-N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)-1H-benzimidazole-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (L)-2-(pyridin-4-yl)-N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)-1H-benzimidazole-4-carboxamide(1309042-24-7)
• EPA Substance Registry System: (L)-2-(pyridin-4-yl)-N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)-1H-benzimidazole-4-carboxamide(1309042-24-7)

Safety Data

• Hazardous Substances Data: 1309042-24-7(Hazardous Substances Data)

Upstream product

• 603-81-6 2,3-diaminobenzoic acid 
• 77326-45-5 2-carbamoyl-3-nitrobenzoic acid 
• 119-62-0 (1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol 
• 124340-93-8 2-(pyridyl-4-yl)-1H-benzimidazole-4-carboxylic acid 
• 606-18-8 3-nitroanthranilic acid 
• 603-11-2 3-nitrophthalic acid 
• 641-70-3 3-nitrophthalic acid anhydride 

Relevant articles and documents

Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses

A series of novel benzimidazole derivatives were designed, synthesized, and evaluated for their activities against four kinds of enteroviruses, that is, Coxsackie virus A16, B3, B6 and Enterovirus 71 in VERO cells. Strong activities against enterovirus replication and low cytotoxicities were observed in these benzimidazoles generally. The most promising compound was (l)-2-(pyridin-2-yl)- N-(2-(4-nitrophenyl)pentan-3-yl)-1H-benzimidazole-4-carboxamide (16), with a high antiviral potency (IC50 = 1.76 μg/mL) and a remarkable selectivity index (328). These compounds were selected for further evaluation as novel enterovirus inhibitors.