1309251-02-2

Basic information

• Product Name: (3S,4S)-4-((3S,4S)-4-((3S,4S)-4-(ε-(N-isovalerylamino)hexanoyl)amino-3-hydroxy-6-methylheptanoylamino)-5-cyclohexyl-3-hydroxypentanoylamino)-3-hydroxy-6-methylheptanoic acid N-isoamylamide
• CAS NO: 1309251-02-2
• Molecular Weight: 796.145
• Mol File: 1309251-02-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,4S)-4-((3S,4S)-4-((3S,4S)-4-(ε-(N-isovalerylamino)hexanoyl)amino-3-hydroxy-6-methylheptanoylamino)-5-cyclohexyl-3-hydroxypentanoylamino)-3-hydroxy-6-methylheptanoic acid N-isoamylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-4-((3S,4S)-4-((3S,4S)-4-(ε-(N-isovalerylamino)hexanoyl)amino-3-hydroxy-6-methylheptanoylamino)-5-cyclohexyl-3-hydroxypentanoylamino)-3-hydroxy-6-methylheptanoic acid N-isoamylamide(1309251-02-2)
• EPA Substance Registry System: (3S,4S)-4-((3S,4S)-4-((3S,4S)-4-(ε-(N-isovalerylamino)hexanoyl)amino-3-hydroxy-6-methylheptanoylamino)-5-cyclohexyl-3-hydroxypentanoylamino)-3-hydroxy-6-methylheptanoic acid N-isoamylamide(1309251-02-2)

Safety Data

• Hazardous Substances Data: 1309251-02-2(Hazardous Substances Data)

Upstream product

• 51583-91-6 N-isovaleryl-6-aminohexanoic acid 
• 128372-97-4 N-tert-butoxycarbonyl-6-aminohexanoic acid methyl ester 
• 100002-32-2 H-(SS)-Sta-OEt 
• 1926-80-3 methyl 6-aminocaproate hydrochloride 
• 98105-43-2 (3S)-3-hydroxy-(4S)-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentanoic acid ethyl ester 
• 98105-45-4 (3S,4S)-4-(N-tert-butoxycarbonyl)amino-5-cyclohexyl-3-hydroxypentanoic acid 
• 67010-43-9 (3S,4S)-ethyl 4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoate 
• 58521-49-6 (3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid 
• 1309251-01-1 C₂₄H₄₇N₃O₄*ClH 
• 1309251-00-0 C₂₉H₅₅N₃O₆ 
• 1309250-99-4 C₂₁H₄₀N₂O₅ 
• 105167-03-1 C₁₃H₂₈N₂O₂ 
• 103808-88-4 C₁₈H₃₆N₂O₄ 

Relevant articles and documents

New potential renin inhibitors with dipeptide replacements in the molecule

A series of eight non-peptidic potential renin inhibitors have been designed and synthesized. All of them contain dipeptide replacement: (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid (ACHPA) in their molecules. Four among them comprise two additional analogs of dipeptide: (3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid (AHPPA) and (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (statine, Sta). All of the synthesized compounds contain also hydrophobic portions to receive a moderate lipophilicity of the molecules. Inhibitory activity of the compounds was measured in vitro by HPLC determination of Leu-Val-Tyr-Ser released from the N-acetyltetradecapeptide substrate by renin in the presence of the inhibitor. Asp-α(OEt)-(S,S)-ACHPA-εAhx-Iaa (23) shows inhibitory activity (7%) at the concentration of 1.0 × 10-2 M. The other synthesized compounds show no inhibitory activity up to this concentration.