1309370-32-8

Basic information

• Product Name: (S)-methyl 1,3-dibenzyl-5-(4-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylate
• CAS NO: 1309370-32-8
• Molecular Weight: 508.533
• Mol File: 1309370-32-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-methyl 1,3-dibenzyl-5-(4-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 1,3-dibenzyl-5-(4-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylate(1309370-32-8)
• EPA Substance Registry System: (S)-methyl 1,3-dibenzyl-5-(4-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylate(1309370-32-8)

Safety Data

• Hazardous Substances Data: 1309370-32-8(Hazardous Substances Data)

Upstream product

• 179990-59-1 (2S,4R)-4-hydroxy-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester 
• 555-16-8 4-nitrobenzaldehdye 
• 124-41-4 sodium methylate 

Relevant articles and documents

Pyrrolo[3,2-e][1,4]diazepin-2-one synthesis: A head-to-head comparison of soluble versus insoluble supports

Aryldiazepin-2-ones are known as "privileged structures", because they bind to multiple receptor types with high affinity. Toward the development of a novel class of aryldiazepin-2-one scaffolds, the synthesis of pyrrolo[3,2-e][1,4]diazepin-2-ones on a support was explored starting from N-(PhF)-4-hydroxyproline and featuring an acid-catalyzed Pictet-Spengler reaction to form the diazepine ring. Three supports [Wang resin, tetraarylphosphonium (TAP) soluble support, and Merrifield resin] were examined in the synthesis of the heterocycle and exhibited different advantages and disadvantages. Wang resin proved effective for exploratory optimization of the synthesis by identification of intermediates after resin cleavage under mild conditions; however, the acidic conditions of the Pictet-Spengler reaction caused premature loss of resin-bound material. Direct monitoring of reactions by TLC, RP-HPLC-MS, and in certain cases NMR spectroscopy was possible with the TAP support, which facilitated purification of intermediates by precipitation; however, incomplete precipitation of material led to overall yields lower than those from solid-phase approaches on resin. Merrifield resin proved stable to the conditions for the synthesis of the pyrrolo[3,2-e][1,4]diazepin-2-one targets and would be amenable to "split-and-mix" chemistry; however, relatively harsh conditions were necessary for final product cleavage. Perspective for the application of different solid-phase approaches in heterocycle library synthesis was thus obtained by demonstration of the respective utility of the three supports for preparation of pyrrolo[3,2-e][1,4] diazepin-2-one.