1309686-63-2

Upstream product

• 3251-56-7 2-methoxy-4-nitrophenol 
• 1309686-62-1 tert-butyl-[2-(2-methoxy-4-nitro-phenoxy)-ethoxy]-dimethyl-silane 
• 75-36-5 acetyl chloride 

Downstream Products

• 1309686-64-3 acetic acid 2-(4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-2-methoxy-phenoxy)ethyl ester 
• 1309686-65-4 (2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-3-methoxy-phenyl]amide 
• 1366097-16-6 (3R,5'S,7'S,7a'R)-6-chloro-7'-(3-chloro-2-fluorophenyl)-2'-[4-(2-hydroxyethoxy)-3-methoxyphenyl]-5'-(2,2-dimethyl-propyl)-2',3',7',7a'-tetrahydrospiro[indoline-3,6'-pyrrolo[1,2-c]imidazole]-1',2(5'H)-dione 

Relevant academic research and scientific papers

BIARYL ACETAMIDE COMPOUNDS AND METHODS OF USE THEREOF

Biaryl acetamide compounds and compositions and their methods of use are provided for modulating the activity of class III receptor tyrosine kinases and for the treatment, prevention or amelioration of one or more symptoms of disease of disorder mediated by class III receptor tyrosine kinases.

Substituted Spiro[3H-Indole-3,6'(5'H)-[1H]Pyrrolo[1,2c]Imidazole-1',2(1H,2'H)-diones

There are provided compounds of the formula wherein X, Y, R1, R1′, R2, R2′, R3, R4, R5 and R6 are as described herein and enantiomers or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as anticancer agents.

SPIROINDOLINONE PYRROLIDINES

There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.