1309686-64-3

Upstream product

• 392332-35-3 6-chloro-2-oxindole 
• 85070-48-0 2-fluoro-3-chlorobenzaldehyde 
• 56341-37-8 6-chloro-2-oxindole 
• 1309686-63-2 2-(2-methoxy-4-nitrophenoxy)ethyl acetate 
• 1309686-62-1 tert-butyl-[2-(2-methoxy-4-nitro-phenoxy)-ethoxy]-dimethyl-silane 
• 1309685-95-7 (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxylic acid trifluoroacetic acid 
• 1309685-92-4 rac-(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid tert-butyl ester 
• 1219086-34-6 2-[(E)-(3,3-dimethylbutylidene)amino]acetic acid tert-butyl ester 
• 897365-76-3 (3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 3251-56-7 2-methoxy-4-nitrophenol 

Downstream Products

• 1309686-65-4 (2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-3-methoxy-phenyl]amide 
• 1366097-16-6 (3R,5'S,7'S,7a'R)-6-chloro-7'-(3-chloro-2-fluorophenyl)-2'-[4-(2-hydroxyethoxy)-3-methoxyphenyl]-5'-(2,2-dimethyl-propyl)-2',3',7',7a'-tetrahydrospiro[indoline-3,6'-pyrrolo[1,2-c]imidazole]-1',2(5'H)-dione 

Relevant academic research and scientific papers

Substituted Spiro[3H-Indole-3,6'(5'H)-[1H]Pyrrolo[1,2c]Imidazole-1',2(1H,2'H)-diones

There are provided compounds of the formula wherein X, Y, R1, R1′, R2, R2′, R3, R4, R5 and R6 are as described herein and enantiomers or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as anticancer agents.

SPIROINDOLINONE PYRROLIDINES

There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.