1309781-30-3Relevant academic research and scientific papers
Microwave-assisted Friedl?nder synthesis of polysubstituted quinolines based on poly(ethylene glycol) bound acetoacetate
Zhang, Xiao-Liang,Hu, Qiao-Sheng,Sheng, Sheng-Ri,Xiao, Chen,Cai, Ming-Zhong
, p. 18 - 23 (2011)
Polysubstituted quinolines were efficiently prepared on the soluble polyethylene glycol (PEG) by microwave irradiation Friedl?nder condensation of PEG bound acetoacetate with 2-aminoarylketones promoted by catalytic amount of polyphosphoric acid, and subsequently cleavage from the PEG withMeONa in MeOH. The polymer-supported synthesis provided the target compounds in excellent yield and purity with a facile work-up procedure.
