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Upstream product

• 20487-40-5 tert-butyl propionate 
• 589-18-4 4-Methylbenzyl alcohol 
• 106-42-3 para-xylene 
• 802294-64-0 propionic acid 
• 104-81-4 4-Methylbenzyl bromide 
• 123-62-6 propionic acid anhydride 
• 104-82-5 4-Methylbenzyl chloride 

Relevant academic research and scientific papers

New alkyne esters and alkyneamide plant antibacterial agents

The present invention relates to a class of propyne esters and propyneamide compounds and synthetic methods thereof, and drugs containing the compound and applications thereof. The two types of compounds have efficient and broad-spectrum inhibitory activity for more than ten kinds of plant pathogenic fungi, and at the same time have the characteristics of simple structure, easy large-scale preparation and high safety of animals and plants, and can be used as active ingredients for the development of new plant antibacterial agents with high efficiency and low toxicity.

Manganese-catalyzed direct C-C coupling of α-C-H bonds of amides and esters with alcohols: Via hydrogen autotransfer

Herein we report an efficient manganese-catalyzed C-alkylation of unactivated amides and tert-butyl acetate using alcohols as alkylating agents. This elegant approach exhibits a broad substrate scope providing the C-C coupled products of amides via a hydrogen auto-transfer strategy using aryl, heteroaryl, and aliphatic alcohols.

Non-directed, carbonate-mediated C-H activation and aerobic C-H oxygenation with Cp?Ir catalysts

The effect of oxidatively stable L- and X-type additives on the activity of Cp?Ir catalyst precursors in the C-H activation of arenes has been studied. Turnover numbers for C-H activation of up to 65 can thus be achieved, as determined by H/D exchange in MeOH-D4. In particular, carbonate additives are found to enhance the C-H activation reactivity of Cp?Ir(H2O)3(OTf)2 (1) more significantly than L-type ligands investigated in this study. Based on these studies, Cp?Ir/carbonate systems are developed that catalyze the aerobic Csp3-H oxygenation of alkyl arenes, employing air as oxidant.

Esterification of carboxylic acids with alkyl halides using imidazolium based dicationic ionic liquids containing bis-trifluoromethane sulfonimide anions at room temperature

Task-specific room temperature ionic liquids (RTILs) composed of symmetrical N-methylimidazolium rings linked with a short oligo (ethylene glycol) chain (cationic part) and bis-trifluoromethane sulfonimide (NTf2, anionic part) were successfully synthesized, and their physicochemical properties were determined by various modern analytical techniques. The catalytic activity of the synthesized RTILs was evaluated in the esterification reaction of acids with alkyl halides in solvent-free conditions at room temperature. From the screening test, all the synthesized RTILs showed a high yield with significant selectivity for respective esters in a very short reaction time. Especially, 0.1 equimolar of RTIL-1 ([tetraEG(mim)2][NTf2]2) was found to be, the most efficient and reusable catalyst for this reaction. As a result, 100% conversion and up to a 94% yield of the respective ester product was obtained in a 30 min reaction time. This might be due to their synergetic effect of Lewis acidity, wide liquid range, and high miscibility compared to the other homogeneous and heterogeneous catalysts. Beside this, RTIL was easily separated from the reaction mixture and reused several times without any significant loss of catalytic activity and structural property. The present dicationic ionic liquids (ILs) under a solvent-free catalytic system were found to be kinetically fast, naturally benign, and achieved good yields for esterification of carboxylic acids with alkyl halides.

Microwave oven synthesis of esters promoted by imidazole

Using imidazole as promotion agent, primary, secondary and phenolic alcohol compounds were esterified with aliphatic and aromatic carboxylic acid anhydrides. Heating a ternary mixture of alcohol, anhydride and imidazole in an unmodified microwave oven produced esters in low to high yields, depending on the steric bulk of the alcohol.

Electroreductive Acylation of Benzyl Chlorides with Acid Anhydrides. Stereoselective Formation of (E)-Enol Esters from Benzyl Alkyl Ketones

Electroreduction of benzyl chlorides in the presence of acid anhydrides brought about stereoselective formation of (E)-enol esters of the corresponding benzyl alkyl ketones, the initial acylated products, in good to moderate yields.