1309863-59-9

Basic information

• Product Name: N'-{2-[(2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide
• Synonyms: N'-{2-[(2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide
• CAS NO: 1309863-59-9
• Molecular Weight: 386.475
• Mol File: 1309863-59-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N'-{2-[(2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-{2-[(2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide(1309863-59-9)
• EPA Substance Registry System: N'-{2-[(2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide(1309863-59-9)

Safety Data

• Hazardous Substances Data: 1309863-59-9(Hazardous Substances Data)

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 88-73-3 2-Chloronitrobenzene 
• 19284-81-2 2-(2-nitro)phenylthiophenylamine 
• 76234-38-3 β-(1-Pyrrolidinyl)-Propionic Acid 
• 68207-43-2 {2-[(2-nitrophenyl)thio]phenyl}hydrazine 
• 6317-35-7 ethyl 3-tetrahydro-1H-1-pyrrolilpropanoate 

Relevant articles and documents

N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-yl)-3-(dimethylamino)propanamide (1) as an effective neuroprotectant and selective butyrylcholinesterase inhibitor. In this paper, we have developed a series of N-acylaminophenothiazines obtained from our compound library or newly synthesised. At micro- and sub-micromolar concentrations, these compounds selectively inhibited butyrylcholinesterase (BuChE), protected neurons against damage caused by both exogenous and mitochondrial free radicals, showed low toxicity, and could penetrate into the CNS. In addition, N-(3-chloro-10H-phenothiazin-10-yl)-2-(pyrrolidin-1-yl) acetamide (11) modulated the cytosolic calcium concentration and protected human neuroblastoma cells against several toxics, such as calcium overload induced by an l-type Ca2+-channel agonist, tau-hyperphosphorylation induced by okadaic acid and Aβ peptide.