130994-89-7Relevant academic research and scientific papers
A Common Precursor Approach to Structurally Diverse Natural Products: The Synthesis of the Core Structure of (±)-Clausenamide and the Total Synthesis of (±)-Hyalodendrin
Szulc, Blanka R.,Sil, Bruno C.,Ruiz, Arnaud,Hilton, Stephen T.
, p. 7438 - 7442 (2015)
Structurally diverse natural products from unrelated sources typically require the development of individual synthetic routes. In a novel approach, we have shown that the epidithiodiketopiperazine-derived natural product (±)-hyalodendrin and the core structure of the unrelated pyrrolidine-derived natural product clausenamide can be synthesised from a common synthetic precursor in good yield by simple variation of the reaction conditions. Structurally unrelated natural products often require individual synthetic routes. In our approach, the epidithiodiketopiperazine natural product (±)-hyalodendrin and the core structure of the unrelated pyrrolidine-derived natural product clausenamide were synthesised from a common precursor by simple variation of the reaction conditions.
4,5-Disubstituted 1-Methylimidazoles via Cyclization of Defined α-Aminoketones: Synthesis of Fungerin and Analogues I
Przybyla, Daniel,Nubbemeyer, Udo
, p. 770 - 774 (2017)
A protocol for the chemoselective synthesis of the fungal metabolite fungerin has been developed. First the required N-methyl α-aminoketone was generated starting from sarcosine, propiolic acid, and prenyl bromide. Marckwald thioimidazole cyclization and subsequent sulfur removal delivered the target fungerin as well as an analogue, respectively, displaying defined substitution patterns.
CONTROL OF THE ENANTIOMERIC PURITY OF N-BOC N-METHYLAMINO ACID BUILDING BLOCKS BY A CONVENIENT NMR METHOD
Calmes, Monique,Daunis, Jacques,Elyacoubi, Rabia,Jacquier, Robert
, p. 329 - 334 (1990)
The enantiomeric purity of N-Boc N-methylamino acid methyl esters could be easily and accurately established by measuring at 250 MHz in the presence of Eu(hfc)3 the enantiomeric shift separation of N-Boc and/or N-methyl signals of one of the conformers.
2-ACYL-4-OXY-1,2-DIHYDROPYRROL-5-ONE COMPOUNDS FOR IMPROVING MEMORY AND COGNITIVE FUNCTION
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Page/Page column 87-88, (2014/12/09)
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain compounds of the following formula (for convenience, collectively referred to herein as 2-acyl-4-oxy-1,2-dihydropyrrol-5-one compounds and DHP compounds ), which, inter alia, are useful in methods of improving memory and/or cognitive function, and in the treatment of memory-related disorders and cognitive decline. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions in the treatment of central nervous system (CNS) disorders such as memory deficit, memory-related disorders, disorders associated with cognitive decline, cognitive impairment, including, for example, mild cognitive impairment (MCI), dementia, and Alzheimer's disease.
