CONTROL OF THE ENANTIOMERIC PURITY OF N-BOC N-METHYLAMINO ACID BUILDING BLOCKS BY A CONVENIENT NMR METHOD

Article abstract of DOI:10.1016/S0957-4166(00)86324-7

The enantiomeric purity of N-Boc N-methylamino acid methyl esters could be easily and accurately established by measuring at 250 MHz in the presence of Eu(hfc)3 the enantiomeric shift separation of N-Boc and/or N-methyl signals of one of the conformers.