1309980-17-3 Usage
General Description
1H-Indole-7-carboxamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- is a chemical compound with a molecular formula C16H20N2O2B. It is an indole derivative with a carboxamide group and a boron-containing side chain. 1H-Indole-7-carboxamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- has potential applications in medicinal chemistry, as boron-containing molecules are often used in drug design and development. The specific properties and uses of 1H-Indole-7-carboxamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- would depend on its specific synthetic and structural characteristics, and further research and testing would be needed to determine its exact applications and potential benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 1309980-17-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,9,9,8 and 0 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1309980-17:
(9*1)+(8*3)+(7*0)+(6*9)+(5*9)+(4*8)+(3*0)+(2*1)+(1*7)=173
173 % 10 = 3
So 1309980-17-3 is a valid CAS Registry Number.
1309980-17-3Relevant articles and documents
Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series
Liu, Qingjie,Batt, Douglas G.,Chaudhry, Charu,Lippy, Jonathan S.,Pattoli, Mark A.,Surti, Neha,Xu, Songmei,Carter, Percy H.,Burke, James R.,Tino, Joseph A.
, p. 3080 - 3084 (2018/08/11)
Incorporation of a suitably-placed electrophilic group transformed a series of reversible BTK inhibitors based on carbazole-1-carboxamide and tetrahydrocarbazole-1-carboxamide into potent, irreversible inhibitors. Removal of one ring from the core of these compounds provided a potent irreversible series of 2,3-dimethylindole-7-carboxamides having excellent potency and improved selectivity, with the additional advantages of reduced lipophilicity and molecular weight.
