1211596-82-5

Basic information

• Product Name: 4-bromo-1H-indole-7-carboxamide
• Synonyms: 4-bromo-1H-indole-7-carboxamide;1H-Indole-7-carboxaMide, 4-broMo-
• CAS NO: 1211596-82-5
• Molecular Formula: C9H7BrN2O
• Molecular Weight: 239.06868
• Mol File: 1211596-82-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-bromo-1H-indole-7-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1H-indole-7-carboxamide(1211596-82-5)
• EPA Substance Registry System: 4-bromo-1H-indole-7-carboxamide(1211596-82-5)

Safety Data

• Hazardous Substances Data: 1211596-82-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-bromo-1H-indole-7-carboxamide is used as an intermediate for the synthesis of various pharmaceutical compounds. Its bromine substitution makes it a valuable building block for the development of anti-cancer and anti-inflammatory drugs.
Used in Anti-cancer Drug Development:
4-bromo-1H-indole-7-carboxamide is used as a potential anti-cancer agent. Its unique structure allows it to target specific cellular pathways and mechanisms involved in cancer progression, making it a promising candidate for the development of novel therapeutic agents.
Used in Anti-inflammatory Drug Development:
4-bromo-1H-indole-7-carboxamide is used as a potential anti-inflammatory agent. Its ability to modulate inflammatory pathways and reduce inflammation makes it a candidate for the development of new treatments for inflammatory diseases.
Used in Synthesis of Heterocyclic Compounds:
4-bromo-1H-indole-7-carboxamide is used as a building block for the synthesis of various heterocyclic compounds with potential pharmacological properties. Its unique structure allows for the creation of diverse compounds with potential applications in drug discovery and development.
Used in Photonic Applications:
4-bromo-1H-indole-7-carboxamide is used in photonic applications due to its fluorescence properties. Its ability to emit light upon excitation makes it a candidate for use in various photonic devices and technologies, such as sensors, imaging, and optoelectronics.

Upstream product

• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 126811-31-2 4,7-Dibromo-1H-indole 
• 1211594-25-0 4-bromo-1H-indole-7-carboxylic acid 
• 1167055-46-0 4-bromo-1H-indole-7-carbonitrile 
• 99277-71-1 4-bromo-2-nitrobenzoic acid 
• 1224724-39-3 methyl 4-bromo-1H-indole-7-carboxylate 
• 604788-34-3 4,7-dibromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indole 

Downstream Products

• 1309980-17-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxamide 

Relevant articles and documents

Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series

Incorporation of a suitably-placed electrophilic group transformed a series of reversible BTK inhibitors based on carbazole-1-carboxamide and tetrahydrocarbazole-1-carboxamide into potent, irreversible inhibitors. Removal of one ring from the core of these compounds provided a potent irreversible series of 2,3-dimethylindole-7-carboxamides having excellent potency and improved selectivity, with the additional advantages of reduced lipophilicity and molecular weight.

INDOLE CARBOXAMIDE COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

PRIMARY CARBOXAMIDES AS BTK INHIBITORS

The invention provides carboxamide compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions, including rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, Crohn's disease, inflammatory bowel disease, ulcerative colitis, psoriatic arthritis, psoriasis, ankylosing spondylitis, interstitial cystitis, asthma, systemic lupus erythematosus, lupus nephritis, B cell chronic lymphocytic lymphoma, multiple sclerosis, chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma, B-cell non-Hodgkin's lymphoma, activated B-celllike diffuse large B-cell, lymphoma, multiple myeloma, diffuse large B-celllymphoma, follicular lymphoma, hairy cell leukemia or Lymphoblastic lymphoma.

CARBOLINE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS

Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, formula (I) are useful as kinase modulators, including Btk modulation.