131002-10-3

Basic information

• Product Name: 6-methylisoquinolin-1(2H)-one
• Synonyms: 6-methylisoquinolin-1(2H)-one;6-Methylisoquinolin-1-ol;6-methyl-1,2-dihydroisoquinolin-1-one
• CAS NO: 131002-10-3
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.1846
• Mol File: 131002-10-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 393.92 °C at 760 mmHg
• Flash Point: 231.173 °C
• Appearance: /
• Density: 1.15g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-methylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methylisoquinolin-1(2H)-one(131002-10-3)
• EPA Substance Registry System: 6-methylisoquinolin-1(2H)-one(131002-10-3)

Safety Data

• Hazardous Substances Data: 131002-10-3(Hazardous Substances Data)

Usage

Uses

6-Methylisoquinolin-1(2H)-one (cas# 131002-10-3) is a useful reagent in the preparation of substituted isoquinolones.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 1419, 1990 DOI: 10.1002/jhet.5570270544

Upstream product

• 131002-07-8 2-ethenyl-4-methylbenzamide 
• 874-60-2 4-methyl-benzoyl chloride 
• 1623775-07-4 N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-4-methylbenzamide 
• 630422-65-0 3-meta-tolyl-acryloyl azide 
• 42398-73-2 6-methylisoquinoline 
• 70810-28-5 6-methylisoquinoline N-oxide 
• 108-05-4 vinyl acetate 
• 25563-06-8 N-methoxy-4-methylbenzamide 
• 13162-05-5 n-vinylformamide 
• 99-94-5 p-Toluic acid 
• 131002-03-4 4-methyl-2- bromobenzamide 

Downstream Products

• 209286-73-7 1-chloro-6-methylisoquinoline 
• 1351399-89-7 C₃₁H₂₈INO₅S 
• 300546-02-5 C₃₁H₂₉NO₆ 
• 444898-39-9 C₃₆H₂₉NO₈ 

Relevant articles and documents

Ruthenium(II)-Catalyzed C?H Activation/Annulation of Aromatic Hydroxamic Acid Esters with Enamides Leading to Aminal Motifs

Hydroxamic acid ester directed C(sp2)?H activation/annulation strategy has been reported employing electron-rich enamides under Ru(II)-catalysis to access aminal frameworks. Both N-vinyl acetamide and N-vinyl formamide delivered aminals bearing

Aromatic compounds and preparation method and application thereof

The invention discloses aromatic compounds and a preparation method and application thereof. The preparation method of the aromatic compounds includes the step of performing a cyclization reaction between an amide compound and a benzoic acid compound in the presence of a rhodium catalyst, a metal oxidant and base, wherein the aromatic compounds are isoquinolinone compounds or isocoumarin derivatives, and the amide compound is N-vinylformamide or N-vinylacetamide. Through the synergistic effect of the rhodium catalyst, the metal oxidant and the base, the isoquinolinone compounds or isocoumarinderivatives are obtained through the one-step reaction between the benzoic acid compound and the amide compound. The reaction has simple operation, the raw materials are cheap and easily available, reaction substrates can be selected flexibly according to the required isoquinolinone compounds and the isocoumarin derivatives, and the synthesized isoquinolinone compounds and the isocoumarin derivatives can be used as a backbone structure in multiple biologically active molecules and natural products, and have high practicality.

Iron-Catalyzed C?H Alkynylation through Triazole Assistance: Expedient Access to Bioactive Heterocycles

Triazole assistance enabled the first iron-catalyzed C?H alkynylation of arenes, heteroarenes, and alkenes. The modular TAM directing group set the stage for a sequential C?H alkynylation/annulation strategy with ample scope, enabling the iron-catalyzed assembly of isoquinolones, pyridones, pyrrolones, and isoindolinones with high levels of chemo-, site-, and regioselectivity.