1310063-70-7Relevant academic research and scientific papers
Purinyl N1-directed aromatic C-H oxidation in 6-arylpurines and 6-arylpurine nucleosides
Chamala, Raghu Ram,Parrish, Damon,Pradhan, Padmanava,Lakshman, Mahesh K.
, p. 7423 - 7435 (2013/09/02)
Palladium-catalyzed C-H bond activation and oxidation of C6 arylpurines as well as C6 arylpurine nucleosides can be accomplished using Pd(OAc) 2/PhI(OAc)2 in CH3CN. Despite the presence of four nitrogen atoms in the purine moiety as well as the polyoxygenated saccharide and a labile glycosidic bond in the nucleosides, these reactions can be effectively conducted. Notably, the generally more labile 2′-deoxyribonucleosides also undergo reaction. The reaction conditions can be tuned to yield either monoacetoxylated or diacetoxylated products predominantly. In the course of these investigations, a dimeric Pd II-containing cyclopalladated C6 naphthylpurine derivative has been obtained and crystallographically characterized. This compound is competent in catalyzing the oxidization with PhI(OAc)2, indicating its plausible intermediacy in the chemistry. The X-ray structure of a monoacetoxylated product from this reaction has also been obtained.
Palladium-catalyzed C-H bond functionalization of C6-arylpurines
Guo, Hai-Ming,Rao, Wei-Hao,Niu, Hong-Ying,Jiang, Li-Li,Meng, Ge,Jin, Jia-Jia,Yang, Xi-Ning,Qu, Gui-Rong
supporting information; experimental part, p. 5608 - 5610 (2011/06/21)
A highly regioselective Pd-catalyzed CAr-H bond activation method was developed for the modification of purines (nucleosides) with different functional groups by using purine as a directing group. This approach provides a new access to a variet
