1310328-63-2

Upstream product

• 1155310-19-2 (R)-(-)-2-(1-hydroxy-1-methylethyl)-5-iodo-2,3-dihydrobenzofuran-6-ol 
• 136053-34-4 1-[(tert-butyldimethylsilyl)oxy]-4-ethynylbenzene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 347377-08-6 tert-butyl(4-(2,2-dibromoethenyl)phenoxy)dimethylsilane 

Downstream Products

• 1310328-64-3 (R)-(-)-4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol 

Relevant academic research and scientific papers

HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.