347377-08-6

Upstream product

• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 
• 74-95-3 1,1-dibromomethane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 187407-19-8 3-(4-tert-butyldimethylsilyloxyphenyl)propiolic acid 
• 1569438-34-1 (Z)-3-bromo-5-(3,5-dichloro-4-hydroxybenzylidene)-4-isopropylfuran-2(5H)-one 
• 144256-13-3 1,1-dibromo-2-(4-hydroxyphenyl)ethylene 
• 1569438-60-3 2,6-dichloro-4-(2,2-dibromovinyl)phenol 
• 1569438-49-8 2,6-dichloro-4-ethynylphenol 
• 347377-10-0 (E)-(4-(2-bromovinyl)phenoxy)(tert-butyl)dimethylsilane 
• 136053-34-4 1-[(tert-butyldimethylsilyl)oxy]-4-ethynylbenzene 
• 1310328-64-3 (R)-(-)-4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol 
• 1310328-63-2 (R)-(-)-2-{6-[4-(tert-butyldimethylsilanyloxy)phenyl]-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl}-propan-2-ol 
• 1310328-32-5 {4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenoxy}acetic acid ethyl ester 
• 1310328-31-4 4-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol 
• 1310328-62-1 2-{6-[4-(tert-butyldimethylsilanyloxy)phenyl]-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl}-propan-2-ol 

Relevant academic research and scientific papers

Nickel-catalyzed asymmetric reductive cross-coupling between vinyl and benzyl electrophiles

A Ni-catalyzed asymmetric reductive cross-coupling between vinyl bromides and benzyl chlorides has been developed. This method provides direct access to enantioenriched products bearing aryl-substituted tertiary allylic stereogenic centers from simple, stable starting materials. A broad substrate scope is achieved under mild reaction conditions that preclude the pregeneration of organometallic reagents and the regioselectivity issues commonly associated with asymmetric allylic arylation.

Copper-catalyzed domino route to natural nostoclides and analogues: A total synthesis of nostoclides i and II

An original and convenient domino route to natural nostoclides I and II has been developed using a two-step sequence consisting of a copper-cat-alyzed tandem reaction associated with Suzuki cross-coupling. The methodology employed for this total synthesis appeared to be an interesting and suffi-ciently flexible tool to allow the synthesis of numer-ous analogues of these nostoclides.

Synthesis, electrochemistry and anticancer activity of novel ferrocenyl phenols prepared via azide-alkyne 1,3-cycloaddition reaction

A series of monophenols and diphenols containing the ferrocene-C triazolyl and ferrocene-Ntriazolyl bond were prepared in a cycloaddition reaction of ethynylferrocene with aryl and benzyl azides and in a reaction of azidoferrocene with phenylacetylenes, respectively. The anticancer activity of the prepared compounds against hormone-dependent (MCF-7) and hormone-independent (HCC38) breast cancer cell lines was studied. The investigated compounds exhibited moderate anticancer activity against hormone-independent (IC50 ～ 15-48 μM) cancer cell line and low activity against hormone-dependent cancer cell line (IC50 ～ 84-98 μM).

HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.

ALPHA-SUBSTITUTED VINYLTIN COMPOUND

To provide α-substituted vinyltin useful for the search for function-developing substances such as pharmaceuticals/agrichemicals and functional materials and for the construction of a compound library. An α-substituted vinyltin compound represented by the