1310381-54-4 Usage
Description
3-Oxetaneacetic acid, also known as 3-oxetaneacetic acid, is a carboxylic acid with the chemical formula C5H8O3. It features a cyclic structure that includes a four-membered oxetane ring. 3-Oxetaneacetic acid has garnered interest due to its potential as a building block in organic synthesis, especially for the creation of heterocyclic compounds. The unique structure and reactivity of 3-oxetaneacetic acid render it a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Furthermore, it has demonstrated potential as a chiral auxiliary in organic synthesis, highlighting its versatility and broad applicability in the field of chemistry.
Uses
Used in Organic Synthesis:
3-Oxetaneacetic acid is used as a building block for the synthesis of heterocyclic compounds due to its unique cyclic structure and reactivity.
Used in Pharmaceutical Synthesis:
3-Oxetaneacetic acid is used as an intermediate in the production of pharmaceuticals, contributing to the development of new medications.
Used in Agrochemical Production:
3-Oxetaneacetic acid is utilized as a key intermediate in the synthesis of agrochemicals, aiding in the creation of effective crop protection agents.
Used as a Chiral Auxiliary:
3-Oxetaneacetic acid is employed as a chiral auxiliary in organic synthesis, enhancing the selectivity and efficiency of asymmetric reactions in the production of enantiomerically pure compounds.
Used in Fine Chemicals Industry:
3-Oxetaneacetic acid is used as an intermediate for the synthesis of various fine chemicals, including specialty chemicals and high-value organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1310381-54-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,0,3,8 and 1 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1310381-54:
(9*1)+(8*3)+(7*1)+(6*0)+(5*3)+(4*8)+(3*1)+(2*5)+(1*4)=104
104 % 10 = 4
So 1310381-54-4 is a valid CAS Registry Number.
1310381-54-4Relevant articles and documents
Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials
Tse, Edwin G.,Houston, Sevan D.,Williams, Craig M.,Savage, G. Paul,Rendina, Louis M.,Hallyburton, Irene,Anderson, Mark,Sharma, Raman,Walker, Gregory S.,Obach, R. Scott,Todd, Matthew H.
, p. 11585 - 11601 (2020)
The replacement of one chemical motif with another that is broadly similar is a common method in medicinal chemistry to modulate the physical and biological properties of a molecule (i.e., bioisosterism). In recent years, bioisosteres such as cubane and bicyclo[1.1.1]pentane (BCP) have been used as highly effective phenyl mimics. Herein, we show the successful incorporation of a range of phenyl bioisosteres during the open-source optimization of an antimalarial series. Cubane (19) and closo-carborane (23) analogues exhibited improved in vitro potency against Plasmodium falciparum compared to the parent phenyl compound; however, these changes resulted in a reduction in metabolic stability; unusually, enzyme-mediated oxidation was found to take place on the cubane core. A BCP analogue (22) was found to be equipotent to its parent phenyl compound and showed significantly improved metabolic properties. While these results demonstrate the utility of these atypical bioisosteres when used in a medicinal chemistry program, the search to find a suitable bioisostere may well require the preparation of many candidates, in our case, 32 compounds.
Synthesis method of 3-oxetane acetic acid
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Paragraph 0022; 0031; 0032-0039; 0048-0054; 0064; 0065-0070, (2017/05/13)
The invention belongs to the fields of organic synthesis and medicine synthesis, and especially relates to a synthesis method of 3-oxetane acetic acid. The synthesis method includes the following steps: (1) performing a reaction to 3-oxetanone and benzylo
