131063-54-2

Upstream product

• 106-42-3 para-xylene 
• 1079104-42-9 (1S,2S,4S,5S)-1,4-di-d-camphorosulfonato-2,5-dimethylcyclohexane 
• 4074-22-0 1,4-dimethyl-cyclohexa-1,4-diene 
• 589-90-2 1,4 dimethylcyclohexane 

Downstream Products

• 189210-87-5 (1S,2S,4S,5S)-(+)-2,5-dimethylcyclohexane-1,4-diol bis(methanesulfonate) 
• 1352994-01-4 (1R,2S,4R,5S)-1,4-N,N-bis(p-methylphenylsulfonamino)-2,5-dimethylcyclohexane 
• 1352994-02-5 (1R,2S,4R,5S)-1,4-N,N'-bisphenylsulfonamino-2,5-dimethylcyclohexane 
• 1352994-03-6 (1R,2S,4R,5S)-1,4-N,N'-bismethylsulfonamino-2,5-dimethylcyclohexane 
• 874292-42-9 2,5-dimethyl-7-azabicyclo[2.2.1]heptane 
• 874292-41-8 Methanesulfonic acid (1S,2S,4R,5S)-4-azido-2,5-dimethyl-cyclohexyl ester 
• 683271-28-5 (1R,2S,4R,5S)-(-)-1,4-diazido-2,5-dimethylcyclohexane 

Relevant academic research and scientific papers

Chiral Bicyclo[2.2.2]octane-Fused CpRh Complexes: Synthesis and Potential Use in Asymmetric C?H Activation

A new class of chiral cyclopentadienyl rhodium(I) complexes (CpRhI) bearing C2-symmetric chiral bridged-ring-fused Cp ligands was prepared. The complexes were successfully applied to the asymmetric C?H activation reaction of N-methoxybenzamides with quinones, affording a series of chiral hydrophenanthridinones in up to 82 % yield with up to 99 % ee. Interestingly, structure analysis reveals that the side wall of the optimal chiral CpRhI catalyst is vertically more extended, horizontally less extended, and closer to the metal center in comparison with the classic binaphthyl and spirobiindanyl CpRhI complexes, and may thus account for its superior catalytic performance.

Synthesis of novel 1,4-bissulfonamide ligands for enantioselective addition of diethylzinc to aldehydes

Several novel chiral sulfonamide ligands based on (1R,2S,4R,5S)-1,4- diamino-2,5-dimethylcyclohexane skeleton have been synthesized and their application in the enantioselective addition of diethylzinc to aldehydes was investigated in the presence of Ti(O

Synthesis of optically active 2,5-dialkylcyclohexane-1,4-diols and their application in the asymmetric oxidation of sulfides

A simple and efficient approach to obtain optically pure 1,4-diols was established. The asymmetric oxidation of sulfides to sulfoxides with cumyl hydroperoxide in moderate yields and moderate to high enantioselectivities (up to 84%) catalyzed by chiral Ti/ 1,4-diols complexes has been achieved. A 76% ee value was obtained in the asymmetric synthesis of esomeprazole. Georg Thieme Verlag Stuttgart.

C2-Symmetric nitroxides and their potential as enantioselective oxidants

The synthesis and evaluation of four C2-symmetric nitroxides are presented. The nitroxides were evaluated for their ability to mediate the oxidation of several alcohols and found to have good catalytic activity. One enantioenriched nitroxide was found to kinetically resolve selected secondary alcohols with very modest selectivities.

The Synthesis of New C2-Symmetric Chiral 1,4-Diamino Motif and Application in Catalytic Asymmetric Alkynylation of meso-Epoxides

The efficient asymmetric preparation of the C2-symmetric chiral 1,4-diamine, (1R,2S,4R,5S)-1,4-diamino-2,5-dimethylcyclohexane (5), and its salen ligands is described. With the Mitsunobu reaction as the key step, the overall yield of the four-s

Syntheses of novel chiral 2,5-dialkyl-7-azabicyclo[2.2.1]heptanes and 2,5-dialkyl-7-thiobicyclo[2.2.1]heptanes

New C2-symmetric chiral amines with a rigid bicyclic framework have been synthesized via hydrogenation of monoazides catalyzed by 5% Pd/C in methanol. Enantiomerically pure 2,5-dialkyl-7-thiobicyclo[2.2.1]heptanes were made from readily available materials.