131078-72-3

Upstream product

• 62596-65-0 (2S)-2-isopropyl-1-[(4-methylphenyl)sulfonyl]aziridine 
• 142745-23-1 [(1S)-1-(aminomethyl)-2-methylpropyl]-4-methylbenzenesulfonamide 
• 2026-48-4 (S)-valinol 
• 98-59-9 p-toluenesulfonyl chloride 
• 460743-50-4 ((1S)-1-{[benzyl((2S)-3-methyl-2-{[(4-methylphenyl)sulfonyl]amino}butyl)amino]methyl}-2-methylpropyl)-4-methylbenzenesulfonamide 
• 462119-77-3 N-[(1S)-1-({(4S)-4-isopropyl-3-[(4-methylphenyl)sulfonyl]imidazolidinyl}methyl)-2-methylpropyl]-4-methylbenzenesulfonamide 

Downstream Products

• 417699-64-0 (2S,6S)-4-carboxybenzyl-1,7-ditosyl-2,6-diisopropyl-1,4,7-triazaheptane 
• 462119-81-9 4-methyl-N-[(1S)-2-methyl-1-({((2S)-3-methyl-2-{[(4-methylphenyl)sulfonyl]amino}butyl)[(4-methylphenyl)sulfonyl]amino}methyl)propyl]benzenesulfonamide 
• 462119-84-2 (2S,6S)-2,6-bis(1-methylethyl)-1,4,7-tris(4-methylbenzenesulfonyl)-1,4,7-triazacyclononane 
• 784178-01-4 (2S,6S)-4-acetyl-1,7-di-p-toluenesulfonyl-2,6-di(1-methylethyl)-1,4,7-triazaheptane 
• 417699-65-1 (2S,6S)-2,6-di(1-methylethyl)-1,7-di-p-toluenesulfonyl-1,4,7-triazacyclononane 
• 784178-09-2 1,3-di[(3S,8S)-3,8-di(methylethyl)-4,7-di-p-toluenesulfonyl-1,4,7-triazacyclononan-1-ylmethyl]benzene 
• 784178-04-7 (2S,6S)-4-acetyl-2,6-di(1-methylethyl)-1,7-di-p-toluenesulfonyl-1,4,7-triazacyclononane 
• 784178-07-0 (2S,6S)-2,6-di(1-methylethyl)-4-ethyl-1,7-di-p-toluenesulfonyl-1,4,7-triazacyclononane 

Relevant academic research and scientific papers

Bifurcated, modular syntheses of chiral annulet triazacyclononanes.

Three chiral 2,6-disubstituted tri-N-methyl azamacrocycles have been prepared by modular methods. These macrocycles were accessed from three chiral 1,4,7-triazaheptanes intermediates that were prepared by two independent routes. The first of these routes

A concise, modular synthesis of chiral peraza-macrocycles using chiral aziridines

(equation presented) Novel chiral peraza-macrocycles were synthesized from chiral aziridines as a common building block. Efficient syntheses of chiral [26]-N6, [12]-N4, [9]-N3, and [14]-N4 systems were accomplis

Sulfonamide ligands from chiral aziridines - Application to the titanium-mediated addition of diethylzinc to benzaldehyde

A modular approach was developed for the preparation of chiral, enantiopure sulfonamide ligands with C1, C2, and C3 symmetry by ring opening of chiral N-sulfonylaziridines with ammonia, primary amines, and diamines. The new ligands were assessed in the titanium-mediated addition of diethylzinc to benzaldehyde, giving the product with selectivities up to 76% ee. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

The synthesis of C2-symmetric 1,4,7-triazacyclononane ligands derived from chiral aziridines

An efficient synthetic route for the synthesis of C2-symmetric derivatives of 1,4,7-triazacyclononanes 14 from chiral pool amino acids has been developed. These investigations have shown that competitive formation of piperazines 7 occurs when i

The synthesis of chiral annulet 1,4,7-triazacyclononanes

Novel and flexible routes for the synthesis of chiral ring annulet 2,6-disubstituted 1,4,7-trimethyl-1,4,7-triazamacrocycles are described. Efficient macrocyclisations were realised provided that chiral analogues of N,N-bis-[2-(toluene-sulfonylamino)ethyl]-toluene-4-sulfonamide were used as the nucleophilic components. Complexes prepared, in situ, from these 2,6-disubstituted 1,4,7-trimethyl-1,4,7-triazamacrocycles and manganese(II) catalysed the asymmetric epoxidation of styrene with hydrogen peroxide.