784178-01-4

Upstream product

• 108-24-7 acetic anhydride 
• 131078-72-3 4-methyl-N-((1S)-2-methyl-1-{[((2S)-3-methyl-2-{[(4-methylphenyl)sulfonyl]amino}butyl)amino]methyl}propyl)benzenesulfonamide 

Downstream Products

• 784178-04-7 (2S,6S)-4-acetyl-2,6-di(1-methylethyl)-1,7-di-p-toluenesulfonyl-1,4,7-triazacyclononane 
• 417699-65-1 (2S,6S)-2,6-di(1-methylethyl)-1,7-di-p-toluenesulfonyl-1,4,7-triazacyclononane 
• 784178-09-2 1,3-di[(3S,8S)-3,8-di(methylethyl)-4,7-di-p-toluenesulfonyl-1,4,7-triazacyclononan-1-ylmethyl]benzene 
• 784178-07-0 (2S,6S)-2,6-di(1-methylethyl)-4-ethyl-1,7-di-p-toluenesulfonyl-1,4,7-triazacyclononane 

Relevant academic research and scientific papers

The synthesis of unsymmetrically N-substituted chiral 1,4,7- triazacyclononanes

A number of chiral unsymmetrically N-substituted 1,4,7-triazacyclononane ligands have been prepared by modular methods. The key step in the synthesis centres on the macrocyclisation of three tertiary amide precursors under standard Richman-Atkins conditio