1311288-93-3Relevant academic research and scientific papers
A strategy for suppressing redox stress within mitochondria
Arce, Pablo M.,Khdour, Omar M.,Goldschmidt, Ruth,Armstrong, Jeffrey S.,Hecht, Sidney M.
, p. 608 - 613 (2011/10/04)
An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do so via a catalytic cycle in which both forms of oxidative stress are suppressed simultaneously. Consequently, the compound effectively protects cultured CEM leukemia cells and Friedreich's ataxia fibroblasts from oxidative stress more effectively than idebenone or idebenol.
MULTIFUNCTIONAL RADICAL QUENCHERS AND THEIR USE
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, (2011/09/19)
The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
