1311288-87-5Relevant academic research and scientific papers
Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases
Goldschmidt, Ruth,Arce, Pablo M.,Khdour, Omar M.,Collin, Valerie C.,Dey, Sriloy,Jaruvangsanti, Jennifer,Fash, David M.,Hecht, Sidney M.
, p. 969 - 978 (2013/03/14)
Two new aza analogues of the neuroprotective agent idebenone have been synthesized and characterized. Their antioxidant activity, and ability to augment ATP levels have been evaluated in several different cell lines having suboptimal mitochondrial function. Both compounds were found to be good ROS scavengers, and to protect the cells from oxidative stress induced by glutathione depletion. The compounds were more effective than idebenone in neurodegenerative disease cells. These novel pyrimidinol derivatives were also shown to augment ATP levels in coenzyme Q10-deficient human lymphocytes. The more lipophilic side chains attached to the pyrimidinol redox core in these compounds resulted in less inhibition of the electron transport chain and improved antioxidant activity.
MULTIFUNCTIONAL RADICAL QUENCHERS AND THEIR USE
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, (2011/09/19)
The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
A strategy for suppressing redox stress within mitochondria
Arce, Pablo M.,Khdour, Omar M.,Goldschmidt, Ruth,Armstrong, Jeffrey S.,Hecht, Sidney M.
, p. 608 - 613 (2011/10/04)
An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do so via a catalytic cycle in which both forms of oxidative stress are suppressed simultaneously. Consequently, the compound effectively protects cultured CEM leukemia cells and Friedreich's ataxia fibroblasts from oxidative stress more effectively than idebenone or idebenol.
