1311291-89-0Relevant academic research and scientific papers
A metal-free hydrogenation of 3-substituted 2H-1,4-benzoxazines
Wei, Simin,Feng, Xiangqing,Du, Haifeng
, p. 8026 - 8029 (2016)
A metal-free hydrogenation of 3-substituted 2H-1,4-benzoxazines has been successfully realized with 2.5 mol% of B(C6F5)3 as a catalyst to furnish a variety of 3,4-dihydro-2H-1,4-benzoxazines in 93-99% yields. Up to 42% ee was also achieved for the asymmetric hydrogenation with the use of a chiral diene and HB(C6F5)2.
Method for preparing 3,4-dihydrobenzo[b][1,4]oxazine derivatives
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, (2016/10/10)
The invention provides a method for preparing 3,4-dihydrobenzo[b][1,4]oxazine derivatives. The method comprises the following step: carrying out reduction reaction on [b][1,4]oxazines in the presence of hydrogen gas by using B(C6F5)3 as a catalyst to obtain the mixture containing the 3,4-dihydrobenzo[b][1,4]oxazines disclosed as Formula I. Benzo[b][1,4]oxazines in different structures are used as a substrate to synthesize the benzo[b][1,4]oxazines at high yield by using the B(C6F5)3 as the catalyst. The method has the advantages of cheap and accessible raw materials, high reaction activity, no participation of transition metals and wide substrate application range, and has huge industrialization potential.
Iridium-catalyzed asymmetric hydrogenation of 3-substituted 2H-1,4-benzoxazines
Gao, Kai,Yu, Chang-Bin,Wang, Duo-Sheng,Zhou, Yong-Gui
experimental part, p. 483 - 488 (2012/05/04)
The highly enantioselective hydrogenation of 3-aryl-2H-1,4-benzoxazines was achieved using the (cyclooctadiene)iridium chloride dimer/(S)-SegPhos/iodine {[Ir(COD)Cl]2/(S)-SegPhos/I2} system as catalyst with up to 92% ee. The 3-styryl
