1311376-20-1

Basic information

• Product Name: 1-benzyl-4-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole
• Synonyms: 1-benzyl-4-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole
• CAS NO: 1311376-20-1
• Molecular Weight: 288.392
• Mol File: 1311376-20-1.mol

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole(1311376-20-1)
• EPA Substance Registry System: 1-benzyl-4-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole(1311376-20-1)

Safety Data

• Hazardous Substances Data: 1311376-20-1(Hazardous Substances Data)

Upstream product

• 1021949-47-2 1-(4-imidazolyl)-1-(2,3-dimethylphenyl)ethylene 
• 100-39-0 benzyl bromide 
• 1311376-15-4 1-(2,3-dimethylphenyl)-2-nitroethanone 
• 1311376-14-3 2-nitrophenyl 2,3-dimethylbenzoate 
• 1311376-18-7 2-amino-3-(benzylamino)-1-(2,3-dimethylphenyl)prop-2-en-1-one 
• 1311376-17-6 3-(benzylamino)-1-(2,3-dimethylphenyl)-2-nitroprop-2-en-1-one 
• 1311376-16-5 (2,3-dimethylphenyl)-imidazol-1-yl-methanone 
• 21900-46-9 2,3-dimethylbenzoyl chloride 
• 603-79-2 2,3-dimethylbenzoic acid 
• 1311376-19-8 1-(1-benzylimidazol-4-yl)(2,3-dimethylphenyl)methanone 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 86347-14-0 medetomidine 

Relevant articles and documents

METHOD FOR PRODUCING IMIDAZOLE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a novel method for producing an optically active imidazole compound useful as a pharmaceutical. SOLUTION: A production method includes the steps for making a compound represented by formula (3) react with hydrogen gas in the presence of an optically active metal complex catalyst, to obtain a compound represented by formula (4) with high yield and high selectivity (in the formula, R1 is an amino protecting group, and * is an asymmetric carbon atom). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

PROCESS FOR PREPARATION OF MEDETOMIDINE

The present disclosure relates to a process for the preparation of medetomidine, 4-[1-(2,3-Dimethylphenyl)ethyl]- 1H-imidazoIe in an environmentally favourable and commercially feasible manner. Previous methods for the preparation of medetomidine use expensive 4-substituted imidazole derivatives as starting material. A practical way of synthesis is provided in which the imidazole ring is built up during a multi-step process starting from commercially affordable, 2,3-dimethylbenzoic. Mild reaction conditions are used throughout the process.