1311392-79-6Relevant articles and documents
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid
Hieke, Martina,Greiner, Christine,Dittrich, Michaela,Reisen, Felix,Schneider, Gisbert,Schubert-Zsilavecz, Manfred,Werz, Oliver
, p. 4490 - 4507 (2011/09/15)
Various inflammatory diseases are associated with the excessive formation of leukotrienes (LTs) and prostaglandins (PGs). Herein, we present a novel class of dual inhibitors of 5-lipoxygenase (5-LO) and microsomal prostaglandin E 2 synthase-1 (