13114-93-7Relevant academic research and scientific papers
Indole-1-Carboxamides as Kinase Inhibitors
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Paragraph 0237-0238, (2016/05/02)
This invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined herein. The compound
The impact of modular substitution on crystal packing: The tale of two ureas
Koshti, Vijay S.,Thorat, Shridhar H.,Gote, Ravindra P.,Chikkali, Samir H.,Gonnade, Rajesh G.
, p. 7078 - 7094 (2016/10/03)
A small library of 13 (3a-m) compounds with modular positioning of iodide and urea/thiourea groups was synthesized in excellent yields in a single step synthetic protocol. The existence of the anticipated (thio)urea derivatives was unambiguously establish
Highly Enantioselective Pd-Catalyzed Synthesis of P-Stereogenic Supramolecular Phosphines, Self-Assembly, and Implication
Koshti, Vijay S.,Mote, Nilesh R.,Gonnade, Rajesh G.,Chikkali, Samir H.
supporting information, p. 4802 - 4805 (2015/11/09)
Metal-catalyzed asymmetric addition of a secondary phosphine to an aryl halide is one of the most efficient and reliable approaches for the construction of enantiopure carbon-phosphorus bonds. An isolated Pd(II) complex (5) catalyzes the carbon-phosphorus coupling reaction between tolylphenylphosphine (1a) and 3-iodophenylurea (2b), which proceeds with an unprecedented enantiomeric excess (ee) of 97%. The generality of the strategy has been demonstrated by preparing a small library of a new class of P-stereogenic phosphines with an in-built hydrogen bonding motif for the first time. The P-stereogenic phosphines self-assemble on a metal template via deliberately installed hydrogen-bonding motifs and mimic the bidentate ligand coordination. Interestingly, when it was employed in asymmetric hydrogenation, the supramolecular phosphine {1-(3-(phenyl(o-tolyl)phosphanyl)phenyl)urea} (6b) produced the corresponding hydrogenated product with the highest enantiomeric excess of 99% along with excellent conversion, demonstrating the potential of these enantioenriched P-chirogenic supramolecular phosphines in asymmetric catalysis.
