131179-71-0

Basic information

• Product Name: 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE
• Synonyms: 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE;BenzeneacetaMide, 4-hydroxy-N-phenyl-
• CAS NO: 131179-71-0
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• Mol File: 131179-71-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 492.6°Cat760mmHg
• Flash Point: 251.7°C
• Appearance: /
• Density: 1.251g/cm³
• Vapor Pressure: 2.51E-10mmHg at 25°C
• Refractive Index: 1.657
• Storage Temp.: 2-8°C
• PKA: 9.87±0.15(Predicted)
• CAS DataBase Reference: 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE(131179-71-0)
• EPA Substance Registry System: 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE(131179-71-0)

Safety Data

• Hazardous Substances Data: 131179-71-0(Hazardous Substances Data)

Usage

General Description

2-(4-Hydroxy-phenyl)-N-phenyl-acetamide is a chemical compound with the molecular formula C14H13NO2. It is a derivative of acetanilide, with a hydroxyphenyl and phenyl group attached to the nitrogen atom of the acetamide group. 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE has potential pharmacological properties as it has been investigated for its anti-inflammatory and analgesic effects. It also exhibits antioxidant properties and has shown potential in inhibiting certain enzymes. 2-(4-Hydroxy-phenyl)-N-phenyl-acetamide is a versatile compound with potential applications in pharmaceutical and medicinal chemistry.

InChI:InChI=1/C14H13NO2/c16-13-8-6-11(7-9-13)10-14(17)15-12-4-2-1-3-5-12/h1-9,16H,10H2,(H,15,17)

Upstream product

• 99-96-7 4-hydroxy-benzoic acid 
• 28141-24-4 4-hydroxybenzoyl chloride 
• 18982-18-8 allyl 4-hydroxybenzoate 
• 62-53-3 aniline 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 156-38-7 4-hydroxyphenylacetate 

Downstream Products

• 1413429-10-3 2-(4-(2-morpholino-1-ethoxy)phenyl)-N-phenylacetamide 
• 85274-97-1 2-(4-methoxyphenyl)-N-phenylacetamide 
• 85275-19-0 4-[2-(2-Dimethylamino-ethylsulfanyl)-quinolin-3-yl]-phenol 
• 131179-88-9 2-[4-((((phenyl)-amino)-carbonyl)-methyl)phenoxy]-2-methyl propionic acid 
• 85275-18-9 2-chloro-3-p-hydroxyphenylquinoline 

Relevant articles and documents

Anti-tumor application of tocopheroxyl nitrogen oxide as HDAC (Histone Deacetylase) inhibitor

The invention discloses anti-tumor application of tocopheroxyl nitrogen oxide as an HDAC (Histone Deacetylase) inhibitor. A compound has a structural general formula as shown in a formula (I), and the compound has a potential inhibition effect on HDAC, so that more nitrogen and oxygen can be further provided for a ZBG (Zinc Binding Group), multi-length survey and the like can be carried out on a linker, structure modification can be carried out on the existing basis, and the functions of an inhibitor having good selectivity on HDAC subtype and other target points are expected to be found. According to the anti-tumor application disclosed by the invention, synthetic raw materials are relatively cheap, the technology is simple, the purity is higher, the cost is lower, and used reagents are all relatively safe. The compound is expected to be used as a novel HDAC inhibitor type anti-tumor medicine which is strong in selectivity, high in efficiency and low in toxicity.

A straightforward synthesis of N-monosubstituted α-keto amides via aerobic benzylic oxidation of amides

An efficient sodium bicarbonate promoted aerobic oxidation reaction to prepare N-monosubstituted α-keto amides in the presence of n-tetrabutylammonium hydrogensulfate (TBAHS) was described. This reaction provides a very simple and convenient synthetic route to N-monosubstituted α-keto amides from easily available aryl- or heteroarylacetamides in good to high yields without using toxic reagents and harsh conditions.

A highly convenient, efficient, and selective process for preparation of esters and amides from carboxylic acids using Fe3+-K-10 montmorillonite clay

In the presence of Fe3+-K-10 montmorillonite clay as a catalyst, aliphatic carboxylic acids selectively produced the corresponding esters in the presence of aromatic carboxylic acids by treatment with alcohols. Both the aliphatic and aromatic carboxylic acids formed the amides by reacting with the aliphatic amines, but only the aliphatic carboxylic acids yielded the anilides by treatment with aromatic amines. The catalyst is recoverable and recyclable.