85274-97-1

Basic information

• Product Name: 2-(4-methoxyphenyl)-N-phenylacetamide
• Synonyms: 2-(4-methoxyphenyl)-N-phenylacetamide
• CAS NO: 85274-97-1
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.2851
• Mol File: 85274-97-1.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-methoxyphenyl)-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-N-phenylacetamide(85274-97-1)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-N-phenylacetamide(85274-97-1)

Safety Data

• Hazardous Substances Data: 85274-97-1(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 201230-82-2 carbon monoxide 
• 66003-76-7 Diphenyliodonium triflate 
• 104-47-2 p-methoxybenzylnitrile 
• 74384-21-7 phenyl 2-(4-(methoxy)phenyl)acetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 15175-54-9 N,N-dimethyl-4-methoxylbenzylamine 
• 1416982-07-4 1-(4-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate 
• 1439383-43-3 5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1436595-46-8 tert-butyl 4-methoxylphenylacetylenyl ether 
• 3422-01-3 tert-butyl phenylcarbamate 
• 33675-41-1 1-bromo-2-(4-methoxyphenyl)acetylene 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 96719-07-2 N-[2-(4-Methoxy-phenyl)-ethyl]-N-phenyl-benzamide 
• 110487-17-7 {2-[3-(4-Methoxy-phenyl)-quinolin-2-ylsulfanyl]-ethyl}-dimethyl-amine 
• 51009-26-8 N-(2-(4-Methoxyphenyl)ethyl)aniline 
• 85274-80-2 2-chloro-3-(4-methoxyphenyl)quinoline 

Relevant articles and documents

A Concise Total Synthesis of Dictyodendrins F, H, and i Using Aryl Ynol Ethers as Key Building Blocks

We report a concise total synthesis of dictyodendrin F and the first total syntheses of dictyodendrins H and I in six steps. In these syntheses, aryl ynol ethers were employed as the key building blocks to introduce aryl and heteroaryl rings in the dictyodendrins. This rapid synthesis utilized a novel hetero-[2 + 2]-cycloaddition reaction between two aryl ynol ethers to yield a cyclobutenone ring. The cyclobutenone was sequentially converted into a highly substituted carbazole via a retro-4π/6π-electrocyclization-N-acylation cascade reaction to provide the dictyodendrin core. Consecutive intramolecular oxidative coupling and deprotection gave dictyodendrins F, H, and I.

Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines

A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.